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US 10,286,176 B2Granted
Systems and methods for generating nitric oxide
AssigneeThird Pole, Inc.
InventorsDavid G. Zapol, Gregory W. Hall, Wolfgang Scholz
Life of this patent
Estimating the term…
Abstract
Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.
Claims20
A nitric oxide generation system, comprising:
- one or more plasma chambers each including one or more electrodes configured to generate a product gas containing nitric oxide using a flow of a reactant gas through the one or more plasma chambers;
- a controller configured to regulate the amount of nitric oxide generated in the product gas by the one or more electrodes in the one or more plasma chambers using one or more parameters as input to a control algorithm, at least one of the one or more parameters being related to the flow rate of the reactant gas into the one or more plasma chambers;
- a reactant gas source that is configured to provide instantaneous high pressure reactant gas to the one or more plasma chambers;
- a flow controller positioned between the reactant gas source and the one or more plasma chambers and configured to provide a controlled continuous variable flow of the reactant gas from the reactant gas source based on a measurement associated with a medical gas into which the product gas flows;
- and
- one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers,
- wherein the concentration of NO in a combination of the product gas and the medical gas is a target value, and
- wherein the measurement associated with the medical gas is the flow rate of the medical gas such that the air flow of the reactant gas through the one or more plasma chambers is proportional to the flow rate of the medical gas.
5 more elements
A nitric oxide generation system, comprising:
- one or more plasma chambers each including one or more electrodes configured to generate a product gas containing nitric oxide using a flow of a reactant gas through the one or more plasma chambers;
- a controller configured to regulate the amount of nitric oxide generated in the product gas by the one or more electrodes in the one or more plasma chambers using one or more parameters as input to a control algorithm, at least one of the one or more parameters being related to the flow rate of the reactant gas into the one or more plasma chambers;
- a reactant gas source that is configured to provide instantaneous high pressure reactant gas to the one or more plasma chambers;
- and
- a flow controller positioned between the reactant gas source and the one or more plasma chambers and configured to provide a controlled continuous variable flow of the reactant gas from the reactant gas source based on a measurement associated with a medical gas into which the product gas flows,
- wherein the concentration of NO in a combination of the product gas and the medical gas is a target value, and
- wherein the measurement associated with the medical gas is the flow rate of the medical gas such that the air flow of the reactant gas through the one or more plasma chambers is proportional to the flow rate of the medical gas.
4 more elements
A nitric oxide generation system, comprising:
- one or more plasma chambers each including one or more electrodes configured to generate a product gas containing nitric oxide using a flow of a reactant gas through the one or more plasma chambers;
- a controller configured to control the amount of nitric oxide generated in the product gas by the one or more electrodes in the one or more plasma chambers based on a control algorithm with one or more input parameters by varying at least one or more of the flow rate of the reactant gas into the one or more plasma chambers and a plasma power in the one or more plasma chambers;
- a reactant gas source that is configured to provide instantaneous high pressure reactant gas to the one or more plasma chambers;
- and
- a flow controller positioned between the reactant gas source and the one or more plasma chambers and configured to provide a controlled continuous variable flow of the reactant gas from the reactant gas source based on a measurement associated with a medical gas into which the product gas flows;
- wherein the concentration of NO in a combination of the product gas and the medical gas is a target value, and
- wherein the measurement associated with the medical gas is the flow rate of the medical gas such that the air flow of the reactant gas through the one or more plasma chambers is proportional to the flow rate of the medical gas.
4 more elements
Dependencies are inferred from the claim text.