Shape memory polymer intraocular lenses

An intraocular lens (IOL) comprising a shape memory polymer (SMP), wherein the SMP is derived from a formulation selected from the group consisting of SMP208, SMP209, SMP210, SMP211, SMP212, SMP213, SMP214, SMP215, SMP218, SMP219, and SMP230b, wherein:

• SMP208 comprises tBA (77.5%), UVB (0.5%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP209 comprises tBA (77.0%), UVB (1.0%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP210 comprises tBA (76.0%), UVB (2.0%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP211 comprises tBA (77.5%), UVAM (0.5%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP212 comprises tBA (77.0%), UVAM (1.0%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP213 comprises tBA (76.0%), UVAM (2.0%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP214 comprises tBA (77.3%), UVB (0.7%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP215 comprises tBA (77.45%), UVAM (0.55%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP218 comprises tBA (64.30%), nBA (13.0%), UVB (0.7%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• SMP219 comprises tBA (64.45%), nBA (13.0%), UVAM (0.55%), PEGDMA 1000 (22%), and IRGACURE819 (0.15%);
• and
• SMP230b comprises tBA (59.80%), nBA (12.00%), UVB (0.80%), PEGDMA 1000 (10%), lauroyl peroxide (0.15%), and HPPA (17.50%);
• wherein UVB is 2-methylacrylic acid 3-(3-tert-butyl-5-(5-chlorobenzotriazol-2-yl)-4-hydroxyphenyl]-propyl ester, UVAM is 2-(2-hydroxy-3-tert-butyl-5-vinylphenyl)-5-chloro-2H-benzotriazole (UVAM), and IRGACURE819 is phenylbis(2,4,6-trimethylbenzoyl) phosphine oxide,
• the IOL having:
• a refractive index above 1.45;
• a Tg between 10° C. and 60° C., inclusive:
• de minimis or an absence of glistening;
• and
• substantially 100% transmissivity of light in the visible spectrum.

An intraocular lens (IOL) comprising a shape memory polymer (SMP), wherein the SMP is derived from a formulation comprising:

• 50-85 wt % tert-butyl acrylate (tBA);
• 3-25 wt % of one or more poly(ethylene glycol) dimethacrylate (PEGDMA) monomers having a number average molecular weight (Mn) ranging from 500 g/mol to 2,000 g/mol;
• n-butyl acrylate (nBA);
• and
• 2-hydroxy-3-phenoxypropyl acrylate (HPPA),
• the IOL having:
• a refractive index above 1.45;
• a Tg between 10° C. and 60° C., inclusive;
• de minimis or an absence of glistening;
• and
• substantially 100% transmissivity of light in the visible spectrum.