Organophosphorous, multivalent metal compounds, and polymer adhesive interpenetrating network compositions and methods
AssigneeHowmedica Osteonics Corp.
InventorsVenkat R. Garigapati, Brian J. Hess, Cassandra L. Kimsey, Matthew E. Murphy
Life of this patent
Estimating the term…
Abstract
Certain small molecule amino acid phosphate compounds such as phosphoserine and certain multivalent metal compounds such as calcium phosphate containing cements have been found to have improved properties and form an interpenetrating network in the presence of a polymer that contains either an electronegative carbonyl oxygen atom of the ester group or an electronegative nitrogen atom of the amine group as the bonding sites of the polymer surfaces to the available multivalent metal ions.
Claims29
A method of adhering a material to a polymer comprising the steps of:
- placing a composition between the material and the polymer wherein the composition comprises:
- (i) a multivalent metal phosphate compound,
- (ii) an amino acid compound of the formula,
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3 and
- (iii) an aqueous medium
- and
- allowing the composition to cure to form an interpenetrating network at the interface between the composition and the polymer,
- wherein the polymer contains an ester, carbonyl, carbonate, carboxylic acid, amide, amine group or a mixture thereof,
- wherein the concentration of the amino acid compound in the composition is greater than about 100 mM, and
- wherein the composition adheres to the material.
A method of adhering bone fragments together using a composition comprising placing the composition on one or more bone fragments, wherein the composition comprises:
- (i) a multivalent metal phosphate compound,
- (ii) an amino acid compound of the formula,
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3;
- (iii) a polymer;
- and
- (iv) an aqueous medium;
- and
- allowing the composition to cure to form an interpenetrating network,
- wherein the polymer contains an ester, carbonyl, carbonate, carboxylic acid, amide, amine, or a mixture thereof, and
- the concentration of the amino acid compound is greater than about 100 mM.
A method of enhancing screw and/or bone anchor fixation in a subject using a composition comprising placing the composition and screw and/or bone anchor in or on a bone, wherein the composition comprises:
- (i) a multivalent metal phosphate compound,
- (ii) an amino acid compound of the formula,
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3;
- (iii) a polymer;
- and
- (iv) an aqueous medium;
- and
- allowing the composition to cure to form an interpenetrating network,
- wherein the polymer contains an ester, carbonyl, carbonate, carboxylic acid, amide, amine group and a mixture thereof;
- and
- the concentration of the amino acid compound is greater than about 100 mM.
A method of attaching a plate to a material using a composition, comprising placing the composition on the plate and/or material, wherein the composition comprises:
- (i) a multivalent metal phosphate compound,
- (ii) an amino acid compound of the formula,
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3;
- (iii) a polymer;
- and
- (iv) an aqueous medium;
- and
- allowing the composition to cure to form an interpenetrating network,
- wherein the polymer contains an ester, carbonyl, carbonate, carboxylic acid, amide, amine group and mixtures thereof;
- and
- the concentration of the amino acid compound is greater than about 100 mM.
A method of enhancing fixation of a joint replacement prosthesis to a bone in a subject using a composition, comprising placing the composition and the joint replacement prosthesis in or on a bone, wherein the composition comprises:
- (i) a multivalent metal phosphate compound,
- (ii) an amino acid compound of the formula,
- where A is O, CH2, or S;
- R is H, NH2, NHCO(CH2)tCH3 where t is 0 to 2, NH(CH2)xCH3 where x is 0 to 3, NR1R2 where R1 is (CH2)yCH3 and R2 is (CH2)yCH3 where y is 0 to 2, (CH2)zCH3 where z is 0 to 3, where m is 0 to 1, and where n is 0 to 3;
- (iii) a polymer;
- and
- (iv) an aqueous medium;
- and
- allowing the composition to cure to form an interpenetrating network,
- wherein the polymer contains an ester, carbonyl, carbonate, carboxylic acid, amide, amine group and a mixture thereof;
- and
- the concentration of the amino acid compound is greater than about 100 mM.
Dependencies are inferred from the claim text.