Dendri-TAC and their use as theranostics

An amphiphilic dendrimer of generation n comprising:

• an hydrophobic central core of valence 2 or 3;
• generation chains attached to the central core and branching around the core;
• and
• an hydrophilic terminal group at the end of each generation chain;
• wherein,
• n is an integer from 0 to 12;
• the hydrophilic terminal group comprises:
• a cyclodextrin residue,
• a polyethylene glycol (PEG) residue,
• a peptide residue,
• a tris(hydroxymethyl)aminoethane (Tris), or
• a 2-amino-2-methylpropane-1,3-diol;
• the central core being a group of formula (Ia) or (Ib):
• wherein:
• W is RF or a group selected from the group consisting of W0, W1, W2 and W3:
• RF is a C4-C10 perfluoroalkyl or a C1-C24 alkyl group,
• RH is a C1-C24 alkyl group,
• p is 0, 1, 2, 3 or 4;
• q is 0, 1, 2, 3 or 4;
• L is a linear or branched C1-C12 alkylene group, optionally interrupted by one or more —O—, —S—,
• Z is C(═O)NH or NHC(═O),
• R is a C1-C6 alkyl group, and
• e is at each occurrence independently 0, 1, 2, 3 or 4.