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US 10,281,427 B2Granted
Methods of isotachophoresis detection
AssigneeTechnion Research & Development Foundation Limited
InventorsMoran Bercovici, Merav Karsenty, Tally Rosenfeld
Life of this patent
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Abstract
An isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the detection and/or separation of analytes of interest.
Claims18
An isotachophoresis (ITP) apparatus comprising:
- (a) a flow channel comprising at least one first cross-section area and at least one second cross-section area, wherein the ratio between said at least one second cross-section area and said at least one first cross-section area is of 1:2-1:50;
- (b) a first zone and a second zone, said first zone is configured to contain a solution of high effective mobility leading electrolyte (LE) ion, and said second zone is configured to contain a solution of low effective mobility trailing electrolyte (TE) ion;
- and
- (c) a control unit configured to modulate an ITP interface in response to a significant change to a rate of electric current decrease during constant voltage;
- optionally
- wherein said flow channel is configured to be operably connected to at least one anode and at least one cathode.
3 more elements
A system comprising:
- (i) an ITP apparatus comprising:
- (a) a flow channel comprising at least one first cross-section area and at least one second cross-section area, wherein the ratio between said at least one second cross-section area and said at least one first cross-section area is of 1:2-1:50, and
- (b) a first zone and a second zone, said first zone is configured to contain a solution of high effective mobility leading electrolyte (LE) ion, and said second zone is configured to contain a solution of low effective mobility trailing electrolyte (TE) ion;
- and
- (ii) an electric current or voltage sensor;
- and
- (iii) a control unit configured to modulate an ITP interface of said ITP apparatus in response to a significant change to a rate of electric current decrease during constant voltage;
- optionally
- wherein said flow channel is configured to be operably connected to at least one anode and at least one cathode.
6 more elements
A computer program product comprising a non-transitory computer-readable storage medium having program code embodied thereon, the program code executable by at least one hardware processor to:
- (a) detect a significant change in a rate of electric current decrease during constant voltage in a flow channel comprising at least one first cross-section area and at least one second cross-section area, wherein the ratio between said at least one second cross-section area and said at least one first cross-section area is of 1:2-1:50;
- and (b) perform at least one function in response to the significant change of the rate of electric current decrease during constant voltage increase detected in step (a).
Dependencies are inferred from the claim text.