Methods of propagating rhinovirus C in previously unsusceptible cell lines
AssigneeWisconsin Alumni Research Foundation
InventorsJames E. Gern, Yury A. Bochkov, Ann C. Palmenberg
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Abstract
The present invention provides methods of propagating rhinovirus C (RV-C) in a host cell; a host cell comprising an effective amount of a heterologous CDHR3 receptor such that the host cell can support propagation of rhinovirus C; and kits comprising at least one host cell previously unable to support rhinovirus C growth, wherein the host cell comprises a heterologous CDHR3 receptor and a sample of rhinovirus C. Methods of use are also provided.
Claims8
A kit comprising:
- a. at least one host cell able to support rhinovirus C replication, wherein the host cell comprises a heterologous CDHR3 receptor;
- and
- b. a sample of rhinovirus C or rhinovirus C variant.
A kit comprising:
- a. a nucleic acid encoding a CDHR3 receptor;
- and
- b. a sample of rhinovirus C.
A host cell infected with rhinovirus C or rhinovirus C variant, wherein the host cell has been modified to express an effective amount of a CDHR3 receptor and support propagation of rhinovirus C.
Dependencies are inferred from the claim text.