Alkynyl multi-arm polyethylene glycol derivative
AssigneeJenkem Technology Co., Ltd.
InventorsMeina Lin, Xiaomeng Chen
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Abstract
The present invention provides an alkynyl multi-arm polyethylene glycol derivative having a structure of a general formula I or general formula X VIII. In the derivative, X1, X2, X3 and X4 are linking groups, F1, F2, F3 and F4 are end groups, the end groups may be the same or may also be different, and are selected from: hydroxy, carboxyl, ester group, amino, alkynyl or the like, at least one of the end groups is alkynyl, and PEG is the same or different —(CH2CH2O)m—, wherein m is an integer ranging from 3 to 250, and l is an integer greater than or equal to 1. The multi-arm polyethylene glycol derivatives have stronger application flexibility, and have good application prospect in aspects such as organic synthesis, medicine synthesis and medical instruments.
Claims12
An alkynyl multi-arm polyethylene glycol active derivative having a structure of a general formula I or XVII
- wherein:
- PEG is the same or different —(CH2CH2O)m—, m is an integer of average value of 3-250;
- l is an integer ≥1;
- X1, X2, X3 and X4 are linking groups independently selected from the group consisting of C1-12 alkyl, aryl alkyl, ester group, carbonate group, amide group, amide ester group, ether group, and urethane group;
- F1, F2, F3 and F4 are end groups independently selected from the group consisting of the following groups:
- NH2, —COOH, —OCH3,
- and —C≡CH,
- in the alkynyl multi-arm polyethylene glycol derivative of general formula I, only one or two or three of the F1, F2, F3 and F4 is (are) —C≡CH;
- and in the alkynyl multi-arm polyethylene glycol derivative of general formula XVIII, only one or two of the F1, F2 and F4 is (are) —C≡CH.
An alkynyl multi-arm polyethylene glycol active derivative having a structure of a general formula I or XVIII
- wherein:
- PEG is the same or different —(CH2CH2O)m—, m is an integer of average value of 3-250;
- l is an integer ≥1;
- X1, X2, X3 and X4 are independently selected from the group consisting of —(CH2)i—, —(CH2)iNHCO(CH2)j—, —(CH2)iCONH(CH2)j—, —(CH2)iNH—, —(CH2)iOCOO—, —(CH2)iOCONH—, —(CH2)iNHCOO—, —(CH2)iNHCONH—, —OC(CH2)iCOO—, —(CH2)iCOO—, —(CH2)iCONH;
- i is an integer of 1-10 in X1, X2, X3 and X4;
- j is an integer of 1-10 in X1, X2, X3 and X4;
- F1, F2, F3 and F4 are end groups independently selected from the group consisting of the following groups:
- NH2, —COOH, —OCH3,
- and —C≡CH,
- in the alkynyl multi-arm polyethylene glycol derivative of general formula I, only one or two or three of the F1, F2, F3 and F4 is (are) —C≡CH;
- and in the alkynyl multi-arm polyethylene glycol derivative of general formula XVIII, only one or two of the F1, F2 and F4 is (are) —C≡CH.
An alkynyl multi-arm polyethylene glycol active derivative, wherein, having following general structure:
- wherein:
- PEG is the same or different —(CH2CH2O)m—, m is an integer of average value of 3-250;
- l is an integer ≥1;
- X1 is selected from of the groups consisting of —(CH2)i—, —(CH2)iNHCO(CH2)j—, —(CH2)iCONH(CH2)j—, —(CH2)iNH—, —(CH2)iOCOO—, —(CH2)iOCONH—, —(CH2)iNHCOO—, —(CH2)iNHCONH—, —OC(CH2)iCOO—, —(CH2)iCOO—, —(CH2)iCONH—;
- i is an integer of 1-10 in X1;
- j is an integer of 1-10 in X1;
- and k is an integer of 1-10.
Dependencies are inferred from the claim text.