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US 10,280,195 B2Granted
Virus reduction method
AssigneeAgency for Science, Technology and Research
InventorPeter Stanley Gagnon
Life of this patent
Estimating the term…
Abstract
Methods are provided for enhancing reduction of virus and viral DNA levels in protein preparations.
Claims19
A method for reducing virus and viral DNA levels in an acidic preparation comprising a desired protein, the method comprising contacting the acidic preparation with an electropositive surface consisting essentially of one or more primary amines, secondary amines, or both, wherein an operating pH during the contacting step is from about 2.0 to about 4.0.
A method for reducing an amount of a virus in a preparation comprising a virus and a desired protein, the method comprising:
- (i) contacting the preparation with an electropositive surface consisting essentially of one or more primary amines or secondary amines, wherein the preparation has a pH less than 4.0;
- and
- (ii) separating the desired protein from the electropositive surface and the virus, wherein the electropositive surface comprises the virus.
Dependencies are inferred from the claim text.