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US 10,279,026 B2Granted
Antigens and antigen combinations
AssigneeGlaxosmithkline Biologicals SA
InventorsMarco Soriani, Maria Scarselli, Nathalie Norais, Danilo Gomes Moriel, Silvia Rossi Paccani
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Abstract
NTHI protein antigens have been identified and found to be conserved across several Haemophilus influenzae pathogenic strains. They have been isolated, cloned from a reference strain and tested for immunogenicity. Methods for immunization and vaccines derived thereof are also disclosed.
Claims9
An immunogenic composition comprising:
- an effective amount of an adjuvant;
- at least one isolated or recombinant polypeptide antigen from non-typeable Haemophilus influenza selected from a group consisting of:
- NTHI1292 (NT067) and NT113, and
- at least one isolated or recombinant polypeptide antigen from non-typeable Haemophilus influenza selected from the group consisting of:
- NTHI0267 (NT035) and NTHI0409 (NT025).
2 more elements
Dependencies are inferred from the claim text.