PCSK9 peptide vaccine conjugated to a Qbeta carrier and methods of using the same
AssigneeStc.Unm
InventorsAlan Remaley, John T. Schiller, Marcelo Amar, Bryce Chackerian
Life of this patent
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Abstract
A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.
Claims16
An immunogen comprising:
- an antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide linked to a bacteriophage virus-like particle (VLP) Qbeta immunogenic carrier, the antigenic PCSK9 peptide comprising the amino acid sequence NVPEEDGTRFHRQASKC (SEQ ID NO:3).
A method of preventing, alleviating, or treating a dyslipidemia in an individual, the method comprising administering a therapeutically effective amount of an immunogen to the individual, the immunogen comprising:
- an antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide linked to a bacteriophage virus-like particle (VLP) Qbeta immunogenic carrier, the antigenic PCSK9 peptide comprising the amino acid sequence NVPEEDGTRFHRQASKC (SEQ ID NO:3).
A method of preventing, alleviating, or treating a condition selected from atherosclerosis, coronary artery disease, cardiovascular disease, and acute coronary syndrome in an individual, the method comprising administering a therapeutically effective amount of an immunogen to the individual, the immunogen comprising:
- an antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide linked to a bacteriophage virus-like particle (VLP) Qbeta immunogenic carrier, the antigenic PCSK9 peptide comprising the amino acid sequence NVPEEDGTRFHRQASKC (SEQ ID NO:3).
A method of preventing, alleviating, or treating hypertriglyceridemia in an individual, the method comprising administering a therapeutically effective amount of an immunogen to the individual, the immunogen comprising:
- an antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide linked to a bacteriophage virus-like particle (VLP) Qbeta immunogenic carrier, the antigenic PCSK9 peptide comprising the amino acid sequence NVPEEDGTRFHRQASKC (SEQ ID NO:3).
Dependencies are inferred from the claim text.