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US 10,273,549 B2Granted
Engineered skin equivalent, method of manufacture thereof and products derived therefrom
AssigneesVitroLabs Inc, King's College London
InventorsIngvar Helgason, Dusko Ilic
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Abstract
Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
Claims34
A method of making a synthetic leather comprising:
- (a) forming an artificial dermal layer comprising a fibroblast;
- and
- (b) tanning at least a portion of said artificial dermal layer, thereby forming said synthetic leather, wherein said fibroblast is differentiated from an induced pluripotent stem cell.
A tanned synthetic leather, which prior to tanning comprises:
- a layered structure comprising:
- an artificial dermal layer comprising a fibroblast and
- an artificial epidermal layer comprising a keratinocyte,
- wherein said fibroblast or said keratinocyte is differentiated from an induced pluripotent stem cell.
1 more element
An artificial epidermal layer comprising:
- a hair follicle cell and a melanocyte, wherein said melanocyte is differentiated from an induced pluripotent stem cell.
Dependencies are inferred from the claim text.