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US 10,273,464 B2Granted
Methods and isolated protein compositions for isoprenoid diphosphate synthesis
AssigneeThe Salk Institute of Biological Studies
InventorsJoseph P. Noel, Nikki M. Dellas
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Abstract
Provided herein are methods and compositions relating to the synthesis of isoprenoid diphosphates using a mutated isopentenyl phosphate kinase.
Claims6
An isolated protein comprising an amino acid sequence that is at least 90% identical to at least 200 contiguous amino acids of SEQ ID NO:8;
- wherein the amino acid sequence comprises substitution at the position corresponding to Ala63 of SEQ ID NO:8;
- and
- wherein said amino acid sequence is capable of catalyzing a reaction between farnesyl (C15) monophosphate and adenosine triphosphate (ATP) to produce farnesyl (C15) diphosphate.
Dependencies are inferred from the claim text.