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US 10,273,311 B2Granted
Compositions to regulate renalase in the treatment of diseases and disorders
AssigneeYale University
InventorsGary Desir, Abigail Hunt, Jessica O-Rear, Peter Flynn
Life of this patent
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Abstract
The invention provides compositions and methods for binding and inhibiting renalase. In one embodiment, the renalase binding molecule inhibits renalase activity. Thus, in diseases and conditions where a reduction of renalase activity is beneficial, such inhibitory renalase binding molecules act as therapeutics.
Claims8
A composition comprising an isolated monoclonal antibody, wherein the antibody comprises:
- a) the heavy chain CDR1 sequence of SEQ ID NO:11;
- b) the heavy chain CDR2 sequence of SEQ ID NO:12;
- c) the heavy chain CDR3 sequence of SEQ ID NO:13;
- d) the light chain CDR1 sequence of SEQ ID NO:14;
- e) the light chain CDR2 sequence of SEQ ID NO:15;
- and f) the light chain CDR3 sequence of SEQ ID NO:16.
3 more elements
Dependencies are inferred from the claim text.