Chimeric antigen receptor specific for SSEA4 antigen
AssigneeMiltenyi Biotec GmbH
InventorsAndreas Bosio, Olaf Hardt, Andrea Aloia
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Abstract
The present invention provides chimeric antigen receptors (CARs) comprising an antigen binding domain specific for SSEA4, a population of engineered cells expressing said CARs, and a pharmaceutical composition comprising said genetically modified cells expressing said CARs. The pharmaceutical composition may be for use of the treatment of cancer in a subject suffering from cancer, wherein at least a subpopulation of the cancerous cells of said cancer expresses SSEA4.
Claims13
A chimeric antigen receptor (CAR) comprising an antigen binding domain specific for sialyl-glycolipid stage-specific embryonic antigen 4 (SSEA4), wherein the antigen binding domain comprises the amino acid sequences of SEQ ID NO:
- 1 and SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.