Substituted phenyl alkanoic acid compounds as GPR120 agonists and uses thereof

A compound of Formula (I)

• or a tautomer, a stereoisomer, a geometrical isomer, a pharmaceutically acceptable salt, a prodrug, an N-oxide, a S-oxide or a carboxylic acid isostere thereof;
• wherein:
• Ring A is 5- to 12-membered carbocycle, 5- to 12-membered heterocyclyl;
• (C6-C10)aryl, or 5- to 12-membered heteroaryl;
• provided that when q is 1 or 2, and W is a bond, then (C6-C10)aryl excludes naphthyl;
• Ring B is 5- to 12-membered carbocycle;
• Ring C is (C6-C10)aryl;
• W represents a bond, —(CR5R6)p—, —O—, —S— or —NR7—;
• X is —CR5R6—X1— or —X1—CR5R6—, wherein X1 is O, S or NR7
• Y is —(C(R4)2)q—;
• Q is —CO2M, —CONH2, —CONH[(C1-C6)alkyl], —CON[(C1-C6)alkyl]2, —CONHSO2(C1-C6)alkyl or a carboxylic acid isostere;
• M is hydrogen, deuterium or (C1-C6)alkyl;
• represents a single bond or a double bond;
• R1 at each occurrence is independently selected from the group consisting of hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkenyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, (C3-C10)cycloalkyl, heterocyclyl, (C6-C10)aryl, heteroaryl, (C6-C10)aryloxy, cyano, oxo, —NR7R8, —C(O)NR7R8, —C(S)NR7R8, —S(O)tR9 and —C(O)R10;
• R2 at each occurrence is independently selected from the group consisting of hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkenyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, (C3-C10)cycloalkyl, heterocyclyl, (C6-C10)aryl, heteroaryl, (C6-C10)aryloxy, cyano, oxo, —NR7R8, —C(O)NR7R8, —C(S)NR7R8, —S(O)tR9 and —C(O)R10;
• R3 at each occurrence is independently selected from the group consisting of hydrogen, halogen, (C1-C6)alkyl, (C1-C6)alkoxy, hydroxy, (C3-C10)cycloalkyl, heterocyclyl, (C6-C10)aryl, heteroaryl, cyano, −NR7R8, —S(O)tR9 and —C(O)R10;
• R4 at each occurrence is independently selected from the group consisting of hydrogen, (C1-C6)alkyl, halo(C1-C6)alkyl and halogen;
• or
• two R4 groups, together with the carbon atom to which they are attached can combine to form a (C3-C10)cycloalkyl or heterocyclyl;
• R5 and R6 are independently selected from the group consisting of hydrogen, deuterium, (C1-C6)alkyl, halo(C1-C6)alkyl and halogen;
• or
• R5 and R6 together with the carbon atom to which they are attached can combine to form
• i) 5- to 12-membered carbocycle or
• ii) 5- to 12-membered heterocyclyl containing 1, 2, 3 or 4 heteroatoms independently selected from the group consisting of N, O and S;
• R7 and R8 are independently selected from the group consisting of hydrogen, hydroxy, (C1-C6)alkyl, (C1-C6)alkenyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C10)cycloalkyl, heterocyclyl, (C6-C10)aryl, heteroaryl, (C6-C10)aryloxy, —S(O)tR9;
• or
• R7 and R8, together with the nitrogen atom to which they are attached combine to form heterocyclyl;
• R9 and R10 are independently selected from the group consisting of hydrogen, hydroxy, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C6)alkoxy, (C3-C10)cycloalkyl, heterocyclyl, (C6-C10)aryl, heteroaryl and —NR7R8;
• m is 0, 1, 2 or 3;
• n is 0, 1, 2 or 3;
• o is 0, 1 or 2;
• p is 1 or 2;
• q is 1, 2, 3 or 4;
• t is 0, 1 or 2;
• wherein:
• (C1-C6)alkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkenyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, (C6-C10)aryloxy, heterocyclyl, heteroaryl, amino, cyano, nitro, —NH(C1-C6)alkyl, —N[(C1-C6)alkyl]2, —C(O)(C1-C6)alkyl, —C(O)O(C1-C6)alkyl, —C(O)NH2, —C(O)NH(C1-C6)alkyl, —C(O)N[(C1-C6)alkyl]2 and —C(O)NHSO2(C1-C6)alkyl;
• (C3-C10)cycloalkyl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkenyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, amino, cyano and nitro;
• carbocycle is a 5- to 12-membered ring which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkenyl, halo(C1-C6)alkyl, hydroxy, halogen, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C6-C10)aryl, (C3-C10)cycloalkyl, heteroaryl, heterocyclyl, amino, cyano, nitro, —C(O)O(C1-C6)alkyl, —C(O)NR7R8 and —S(O)tR9;
• wherein R7, R8, R9 and t are as defined above;
• heterocyclyl is a 5- to 12-membered ring which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkenyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, amino, cyano, nitro, oxo, —NR7R8, —C(O)NR7R8, —S(O)tR9 and —C(O)R10;
• wherein R7, R8, R9, R10 and t are as defined above;
• (C6-C10)aryl is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkenyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, amino, cyano, nitro, —C(O)O(C1-C6)alkyl, —C(O)NR7R8 and —S(O)tR9;
• wherein R7, R8, R9 and t are as defined above;
• heteroaryl is a 5- to 12-membered ring which is unsubstituted or substituted with one or more groups independently selected from the group consisting of (C1-C6)alkyl, (C1-C6)alkenyl, halogen, halo(C1-C6)alkyl, hydroxy, (C1-C6)alkoxy, halo(C1-C6)alkoxy, (C3-C10)cycloalkyl, (C6-C10)aryl, heterocyclyl, heteroaryl, amino, cyano, nitro, —C(O)NR7R8 and —S(O)tR9;
• wherein R7, R8, R9 and t are as defined above.