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US 10,273,212 B2Granted
Continuous flow carboxylation reaction
AssigneeSarcode Bioscience Inc.
InventorsScott Tweedie, Sripathy Venkatraman, James Zeller
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Abstract
The present invention is related to a two-step carboxylation reaction of an aryl group using continuous flow reaction conditions. This process permits large scale synthesis of useful reaction products in high yield.
Claims10
A process of preparing a compound of Formula I:
- comprising:
- reacting a compound of Formula II:
- with n-BuLi and TMEDA at −78° C. to afford a compound of Formula III:
- quenching said compound of Formula III with gaseous carbon dioxide to afford a compound of Formula IV:
- and
- treating said compound of Formula IV with HCl to afford the compound of Formula I, wherein said method is performed using continuous flow reaction conditions, wherein the carbon dioxide quenching has a residence time of about 5 minutes.
3 more elements
Dependencies are inferred from the claim text.