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US 10,273,202 B2Granted
Nitroxyl progenitor compounds and methods of use
AssigneeThe Johns Hopkins University
InventorsJohn P. Toscano, Christopher M. Pavlos, Preeya Kapur Boppana
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Abstract
Described herein are nitroxyl progenitor compounds, and compositions including, and methods or generating, the compounds thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions.
Claims4
A compound of formula (I), or a pharmaceutically acceptable salt thereof:
- wherein:
- R1 and R2, together with the nitrogen to which they are both attached, form a heteroaryl ring, wherein the heteroaryl ring is pyrrolyl or indolyl;
- wherein the heteroaryl ring is optionally substituted with from 1-4 groups selected from the group consisting of halo, COOH, NO2 and ═O;
- m is 0;
- and
- n is 0.
3 more elements
A compound selected from the group consisting of:
Dependencies are inferred from the claim text.