Punch card programmable microfluidics

An apparatus comprising:

• a support structure including a portion with a recess configured for receiving a chip with a plurality of microfluidic channels;
• a plurality of actuators connected to the support structure, wherein the plurality of actuators rotate relative to the support structure and rotate independently of each other, wherein each actuator of the plurality of actuators includes a plurality of teeth protruding outward from a center of each actuator, and wherein each actuator is positioned so that at least in a first angle of rotation of each actuator a first tooth of each actuator extends into the recess sufficiently to compress a microfluidic channel in the chip placed in the recess;
• and
• a punch card guide comprising a surface wherein a space is formed between the surface and the plurality of actuators on a side of the plurality of actuators opposite the recess, and the space is sized to accommodate a punch card with a plurality of punched features, the punch card guide connected to the support structure and configured to guide the punch card so that at least in a second angle of rotation of each actuator at least a portion of a second tooth of each actuator extends into the space,
• wherein a width of each tooth of the plurality of teeth of each actuator is in a range from about 10 microns to about 1000 microns.