# US 10,272,172 B2 · Multifunctional transdermal dressing for wounds

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- Number: US 10,272,172 B2
- Document ID: US10272172B2
- Status: Granted
- Kind: B2
- Application number: 15/345,122
- Filed: 2016-11-07
- Published: 2018-02-15
- Granted: 2019-04-30
- Earliest claimed: 2013-03-15
- Assignees: Materials Modification, Inc.
- Applicants: Materials Modification Inc.
- Inventors: Krishnaswamy Kasthuri Rangan; Tirumalai Srinivas Sudarshan
- Web page: https://patentgrep.com/patent/US10272172B2

## CPC

- A61L 15/18: containing inorganic materials
- A61F 13/00063: {comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00)}
- A61K 31/167: having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A61K 31/4468: having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
- A61K 33/38: Silver; Compounds thereof
- A61L 15/44: Medicaments
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61F 2013/00157: {for burns or skin transplants (A61F2013/00187 takes precedence; not adhering to the wound A61F2013/00217)}
- A61L 2300/402: Anaestetics, analgesics, e.g. lidocaine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic. The multifunctional polymer-free clay product provides antimicrobial and pain relieving properties. Method of treatment of burns using the multifunctional polymer-free clay product having antimicrobial and pain relieving properties. Methods of preparing multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic.

## Claims

### Claim 1

A method of preparing a multifunctional polymer-free clay film comprising a clay, an antimicrobial agent, a zwitterion and an analgesic, the method comprising:
a) mixing a clay, the antimicrobial agent and water to form a first slurry;
b) centrifuging and washing the first slurry of step a) with water to obtain a washed second slurry;
c) adding a zwitterion and water to the washed second slurry of step b) to obtain a third slurry;
d) casting the third slurry of step c) onto a substrate to obtain a first dried product;
e) adding drops of the analgesic in a non-aqueous solvent onto the first dried product of step d) to obtain a resultant product,
f) drying the resultant product to obtain a second dried product; and,
g) separating the second dried product of step f) from the substrate of step d), wherein the second dried product of steps f) and g) is the multifunctional polymer-free clay film which provides both antimicrobial and pain relieving properties, wherein the zwitterion is selected from the group consisting of N,N,N-trimethylglycine and N,N,N-trimethylglycine hydrochloride, and wherein the antimicrobial agent in the multifunctional polymer-free clay film is selected from the group consisting of silver ion, copper, silver-containing compounds, and, copper containing compounds.

### Claim 2 (depends on 1)

The method of claim 1, wherein the silver-containing compound is silver nitrate.

### Claim 3 (depends on 1)

The method of claim 1, wherein the analgesic is selected from the group consisting of
opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), adjuvant analgesics, cannabinoids and combinations thereof,
wherein the opioid analgesics are selected from the group consisting of Morphine, fentanyl, Buprenorphine, fentanyl base, and combinations thereof,
wherein the adjuvant analgesics are selected from the group consisting of capsaicin, clonidine, ketamine, lidocaine base, loperamide base, and combinations thereof.

### Claim 4 (depends on 1)

The method of claim 1, wherein the substrate is selected from the group consisting of a silicone sheet, a fabric, and a glass surface.

### Claim 5 (depends on 1)

The method of claim 1, wherein the clay is selected from the group consisting of montmorillonite, kaolinite, smectite, and bentonite.

### Claim 6 (depends on 1)

A multifunctional polymer-free clay film prepared by the method of claim 1, wherein the multifunctional polymer-free film provides both antimicrobial and pain relieving properties.