Injectable vaccines against multiple meningococcal serogroups
AssigneeGlaxosmithkline Biologicals SA
InventorPaolo Costantino
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Abstract
An injectable immunogenic composition comprising capsular saccharides from at least two of serogroups A, C, W135 and Y of Neisseria meningitidis, wherein said capsular saccharides are conjugated to carrier protein(s) and/or are oligosaccharides, and wherein (i) the composition comprises <50 μg meningococcal saccharide per dose, and/or (ii) the composition further comprises an antigen from one or more of: (a) serogroup B N. meningitidis; (b) Haemophilus influenzae type B; and/or (c) Streptococcus pneumoniae. Saccharide antigens in the compositions are generally conjugated to a carrier.
Claims22
An injectable immunogenic composition comprising capsular saccharides from N. meningitidis serogroups A, C, W135 and Y, wherein:
- (i) each of said capsular saccharides is conjugated to a carrier protein to give separate conjugates for each of the four serogroups;
- (ii) the total of the capsular saccharides from the N. meningitidis serogroups A, C, W135 and Y per dose of the composition is between about 10 μg and 25 μg;
- and (iii) the capsular saccharides from the N. meningitidis serogroups A, C, W135 and Y are present at a 2:1:1:1 capsular saccharide weight ratio.
Dependencies are inferred from the claim text.