Use of H3K9me3 modulation for enhancing cognitive function
AssigneeThe Regents of the University of California
InventorsCarl W. Cotman, Larry E. Overman, Shikha Snigdha
Life of this patent
Estimating the term…
Abstract
Use of H3K9me3 modulation for enhancing cognitive function and treating anxiety related disorders is presented. A composition is administered to the subject comprising a therapeutically effective amount of a SUV39H1 inhibitor comprising analogs of ETP69. The therapeutically effective amount is effective in treating cognitive dysfunction in aging and age-related disorders.
Claims27
A method of reversing cognition loss in an animal subject in need thereof, the method comprising:
- selecting an animal subject with cognitive loss;
- and
- administering a therapeutically effective amount of a SUV39H1 inhibitor compound to said animal subject, wherein said therapeutically effective amount comprises single dosing for acute treatment and repeated dosing for chronic treatment.
A method of reversing cognition loss in a patient in need thereof, the method comprising:
- selecting a patient with loss of memory function;
- and
- administering to the patient a therapeutically effective amount of a SUV39H1 inhibitor compound together with a pharmaceutical cognitive enhancer, wherein said therapeutically effective amount comprises single dosing for acute treatment and repeated dosing for chronic treatment.
A method of enhancing cognition in a subject in need thereof, the method comprising:
- selecting a subject in need of memory enhancement;
- and
- administering to the subject a therapeutically effective amount of a SUV39H1 inhibitor compound together with a lifestyle cognitive enhancer.
A method of treatment, prevention or alleviation of a cognitive dysfunction of a living animal subject, including a human, the method comprising:
- selecting a living animal subject with signs of cognitive loss;
- and
- administering to such living animal subject a therapeutically effective amount of a SUV39H1 inhibitor compound.
A method of treatment for extinction of conditioned fear in an animal subject, the method comprising:
- selecting an animal subject with conditioned fear behavior;
- and
- administering a therapeutically effective amount of a SUV39H1 inhibitor compound to said animal subject, wherein said therapeutically effective amount comprises single dosing for acute treatment and repeated dosing for chronic treatment.
Dependencies are inferred from the claim text.