Use of liposomes in a carrier comprising a continuous hydrophobic phase as a vehicle for cancer treatment
AssigneeImmunovaccine Technologies Inc.
InventorsPirouz M. Daftarian, Marc Mansour, Bill Pohajdak, Robert G. Brown, Wijbe M. Kast
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Abstract
The invention compositions comprising a continuous hydrophobic phase and liposomes as a vehicle for delivery of an antigen capable of inducing a cytotoxic T lymphocyte (CTL) response and methods for their use in the treatment of cancer.
Claims61
A method for inducing an enhanced cytotoxic T lymphocyte (CTL) response thereby treating cancer or inhibiting or preventing the growth or proliferation of cancer cells in a subject in need of cancer treatment comprising:
- encapsulating at least one antigen comprising a CTL epitope and at least one T helper epitopes in liposomes;
- combining said liposomes with a carrier consisting essentially of oil or a water-in-oil emulsion to form a composition;
- and
- administering said composition to said subject.
A method for inducing an enhanced cytotoxic T lymphocyte (CTL) response thereby treating cancer or inhibiting or preventing the growth or proliferation of cancer cells in a subject in need of cancer treatment comprising administering a composition comprising:
- a carrier consisting essentially of oil or a water-in-oil emulsion;
- liposomes;
- at least one antigen comprising a CTL epitope;
- and
- at least one T helper epitope;
- wherein the antigen and the T helper epitope are encapsulated within said liposomes.
Dependencies are inferred from the claim text.