Treatment of gluten intolerance and related conditions
AssigneeNepetx, LLC
InventorsDavid C. Schriemer, Petr Man, Hynek Mrazek, Martial Rey
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Abstract
Provided herein are compositions, foods comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof for modulating gluten intolerance and related conditions, such as celiac disease. Further provided herein are pharmaceutical compositions comprising nepenthesin or a derivative thereof and methods of using nepenthesin or a derivative thereof to treat bacterial infections of the gastrointestinal tract, such as C. difficile or H. pylori. Further provided herein are compositions comprising recombinant nepenthesin I or nepenthesin II, or homologous proteins, and methods for making the same.
Claims11
A composition comprising a recombinant nepenthesin and a transgenic organism wherein said transgenic organisms expresses said nepenthesin and comprises an expression vector, said expression vector comprising a nucleic acid sequence encoding said nepenthesin, wherein said nepenthesin encoded by said nucleic acid sequence comprises an amino acid sequence that is at least 95% identical to the amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, and SEQ ID NO:
- 7 without a plant signal sequence and having aspartic protease activity, wherein said organism is Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Lactobacillus, or Aspergilli.
An expression vector comprising a nucleic acid sequence encoding a nepenthesin, wherein said nepenthesin encoded by said nucleic acid sequence comprises an amino acid sequence that is at least 95% identical to the amino acid sequence selected from the group consisting of SEQ ID NO:
- 3, SEQ ID NO:
- 4, SEQ ID NO:
- 5, SEQ ID NO:
- 6, and SEQ ID NO:
- 7 without a plant signal sequence and having aspartic protease activity.
Dependencies are inferred from the claim text.