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US 10,266,485 B2Granted
Compounds and compositions for intracellular delivery of therapeutic agents
AssigneeModernaTX, Inc.
InventorKerry E. Benenato
Life of this patent
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Abstract
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.
Claims27
A compound of Formula (II):
- or a salt or isomer thereof, wherein
- l is selected from 1, 2, 3, 4, and 5,
- M1 is M′;
- R4 is —(CH2)nQ, in which Q is OH, and n is selected from 1, 2, 3, 4, or 5;
- M and M′ are independently selected from —C(O)O—, and —OC(O)—;
- R2 and R3 are both C1-14 alkyl, or C2-14 alkenyl;
- and
- R′ is a C1-C12 linear alkyl.
5 more elements
Dependencies are inferred from the claim text.