Pharmaceutical compositions comprising meloxicam
AssigneeAxsome Therapeutics, Inc.
InventorHerriot Tabuteau
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Abstract
Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of conditions such as pain.
Claims20
A method of improving oral bioavailability of meloxicam in a human being, comprising orally administering a solid dosage form comprising both a bicarbonate and meloxicam to the human being, wherein the solid dosage form contains 400 mg to 900 mg of the bicarbonate, wherein the oral bioavailability of meloxicam for the solid dosage form in the human being is improved as compared with a first reference dosage form that:
- 1) contains the same amount of meloxicam;
- 2) does not contain the bicarbonate;
- and 3) does not contain a carbonate, or a second reference dosage form that:
- a) contains the same amount of meloxicam;
- b) does not contain the bicarbonate;
- and c) contains an amount of potassium carbonate that achieves about the same pH as the bicarbonate.
Dependencies are inferred from the claim text.