Pharmaceutical compositions comprising meloxicam
AssigneeAxsome Therapeutics, Inc.
InventorHerriot Tabuteau
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Abstract
Disclosed herein are compositions comprising an NSAID such as meloxicam in combination with a cyclodextrin and/or a carbonate or a bicarbonate. These compositions may be orally administered, for example, to improve the bioavailability or pharmacokinetics of the NSAID for the treatment of conditions such as pain.
Claims20
A method of improving dissolution of meloxicam in the stomach of a mammal, comprising orally administering a solid dosage form comprising both a bicarbonate and meloxicam to the mammal, wherein the dosage form contains 400 mg to 1000 mg of the bicarbonate, and wherein the rate of dissolution of meloxicam for the solid dosage form in simulated gastric fluid is improved as compared with a reference dosage form that:
- 1) contains the same amount of meloxicam;
- 2) contains an amount of potassium carbonate that achieves about the same pH as the bicarbonate;
- and 3) does not contain the bicarbonate.
Dependencies are inferred from the claim text.