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US 10,261,097 B2Granted
Methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders and associated processes
AssigneeC2N Diagnostics
InventorsTim West, Andrew C. Paoletti
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Abstract
The invention generally relates to methods for the diagnosis and treatment of neurological and neurodegenerative diseases, disorders, and associated processes. Specifically, the present invention is directed toward methods to determine prognosis, diagnosis or efficacy of a therapeutic regimen by using a detectable label to measure levels of alpha-synuclein.
Claims12
A method comprising:
- a) administering a labeled moiety to a subject suspected of having Alzheimer's disease (AD), wherein the labeled moiety incorporates into alpha-synuclein thereby producing labeled alpha-synuclein;
- b) obtaining a biological sample from the subject;
- c) determining metabolic incorporation of the labeled moiety into alpha-synuclein in the biological sample, wherein determining the metabolic incorporation comprises measuring the level of labeled alpha-synuclein and unlabeled alpha-synuclein in a polypeptide selected from the group consisting of SEQ ID NOs:
- 4-13 in the biological sample via a stable isotope labeling kinetics (SILK) assay and determining the ratio of labeled alpha-synuclein to unlabeled alpha-syuclein;
- and
- d) comparing the metabolic incorporation of (c) with that of a corresponding normal sample.
3 more elements
Dependencies are inferred from the claim text.