Method for augmenting vision in persons suffering from photoreceptor cell degeneration
AssigneeThe General Hospital Corporation
InventorRichard H. Masland
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Abstract
The invention provides compositions and methods of treating subjects afflicted with a photoreceptor disorder. Methods for treating a subject suffering from a disorder characterized by photoreceptor cell degeneration are provided, wherein a gene encoding a photosensitive protein is introduced into a retinal cell of a subject. In one aspect of the invention, the retinal cells which receive the photosensitive protein include non-photoreceptor cells such as horizontal cells, amacrine cells, bipolar cells, and ganglion cells.
Claims5
A method for improving an eyesight of a subject suffering from age-related macular degeneration characterized by photoreceptor cell degeneration, consisting of injecting intraocularly a recombinant viral vector consisting essentially of a promoter operably linked to a nucleic acid encoding a single polypeptide, wherein said polypeptide is rhodopsin, into a non-photoreceptor retinal cell selected from the group consisting of horizontal cells, amacrine cells, bipolar cells, and ganglion cells of an affected eye of the subject suffering from age-related macular degeneration such that the eyesight of the subject is improved.
Dependencies are inferred from the claim text.