Compositions and methods comprising hydrocarbon-stapled polypeptides
AssigneeDana-Farber Cancer Institute, Inc.
InventorsLoren D. Walensky, Gregory H. Bird
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Abstract
The invention provides compositions, kits and methods utilizing polypeptides having a viral alpha-helix heptad repeat domain in a stabilized α-helical structure (herein also referred to as SAH). The compositions are useful for treating and/or preventing viral infections. The invention is based, at least in part, on the result provided herein demonstrating that viral hydrocarbon stapled alpha helical peptides display excellent proteolytic, acid, and thermal stability, restore the native alpha-helical structure of the peptide, are highly effective in interfering with the viral fusogenic process, and possess superior pharmacokinetic properties compared to the corresponding unmodified peptides.
Claims15
A cross-linked polypeptide comprising a stabilized alpha helix of a viral heptad repeat (HR) domain, wherein the stabilized HR domain is stabilized with two hydrocarbon staples, and wherein a hydrocarbon staple is positioned so as to link amino acid residues i and i+3, amino acid residues i and i+4, or amino acid residues i and i+7.
Dependencies are inferred from the claim text.