Methods, compositions, and kits using heterogeneous catalysts
AssigneeOccidental College
InventorsMichael Hill, Andrew Udit
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Abstract
Described herein are methods, compositions and kits utilizing heterogeneous metal catalysts for the preparation of cycloaddition compounds, such as triazoles and biomolecules.
Claims20
A method for preparing a cycloaddition compound from a reaction catalyzed by a heterogeneous copper catalyst, comprising
- (a) mixing an alkyne component and an azide component in an appropriate solvent to form a solution containing the alkyne component and the azide component;
- (b) preparing a column matrix by mixing a copper (II) precatalyst with an ion exchange resin to form a suspension and then adding a reducing agent to the suspension;
- wherein a copper (I) catalyst is generated from the reduction of the copper (II) precatalyst with the reducing agent;
- (c) transferring the column matrix of step (b) to a centrifuge column having a matrix barrier at the bottom of the column, wherein the centrifuge column is packed with a column matrix consisting of a size-exclusion resin;
- and
- (d) passing the solution containing the alkyne component and the azide component through the centrifuge column;
- wherein upon contact with the copper (I) catalyst within the matrix, the alkyne component and the azide component react to form the cycloaddition compound and to yield a solution containing the cycloaddition compound.
A column matrix suitable for use in centrifugal column chromatography consisting of a heterogeneous copper catalyst that catalyzes an azide-alkyne cycloaddition and is mixed with an ion-exchange resin, and a size-exclusion resin.
A column suitable for use in centrifugal column chromatography comprising a heterogeneous copper catalyst that catalyzes an azide-alkyne cycloaddition and a column matrix consisting of an ion-exchange resin and a packed size-exclusion resin.
Dependencies are inferred from the claim text.