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US 10,259,780 B2Granted
Treatment of cataplexy
AssigneesJazz Pharmaceuticals International III Limited, SK Biopharmaceuticals Co., Ltd.
InventorsMoise A. Khayrallah, Gary Bream, Stephen E. Butts
Life of this patent
Estimating the term…
Abstract
The present invention relates to a method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of certain carbamate compounds.
Claims12
A method of treating cataplexy in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt or ester thereof;
- wherein R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and 1, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms;
- x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
- R1 and R2 are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, phenyl, and cycloalkyl of 3 to 7 carbon atoms;
- or
- R1 and R2 can be joined to form a 5 to 7-membered unsubstituted heterocycle, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.
3 more elements
Dependencies are inferred from the claim text.