US 10,258,941 B2Granted

Apparatus and methods for preparing an emulsion

AssigneeEvonik Corporation

InventorsBruce W. Hudson, Gary W. Opperman, Adrian T. Raiche

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Abstract

Disclosed herein are apparatus and methods for producing emulsions, and, in particular, for maintaining laminar flow during production of emulsions containing microsuspensions. Disclosed herein are columns for receiving a packing material that permits fluid flow through the column. The columns have a periphery that defines an interior cavity in fluid communication with inlets and outlets of the column. Disclosed herein is a method of preparing an emulsion that includes (1) forming a first phase typically containing an organic solvent, a polymer, and one or more biologically active agents and/or chemicals; (2) forming a second phase typically containing water as the second solvent, an emulsion stabilizer and optionally a solvent; and (3) passing the first and the second phases through the column to form a “water in oil” type emulsion.

Claims10

Dependent claims

A method of preparing an emulsion, the method comprising:

positioning a packing material within a column, the column having a longitudinal axis and a periphery defining an interior cavity, the interior cavity having a longitudinal length;
the packing material configured to permit fluid flow through the column along the longitudinal axis, the column comprising:
an inlet in fluid communication with the interior cavity;
an outlet in fluid communication with the interior cavity;
and
at least one divider positioned within the interior cavity, each divider of the at least one divider extending along at least a portion of the longitudinal length of the interior cavity,
wherein the at least one divider is configured to partition the packing material and direct fluid flow therethrough the interior cavity;
introducing a plurality of fluids through the inlet of the column under laminar flow conditions, wherein the plurality of fluids combine within the interior cavity of the column to form an emulsion product;
and
collecting the emulsion product through the outlet of the column;
wherein the method is insensitive to flow rates;
and
wherein the column can be utilized at any pressure.

10 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/334,154Filed 22 Dec 2011 · us provisional application
Priority: 23 Dec 2010
Published: US 2012/0178629 A112 Jul 2012
Granted: 16 Apr 2019
Term ends: Not estimatedThe source records don’t support an estimate.

Classification30 codes

B01F 23/41
Mixing liquids with liquids; Emulsifying: emulsifying
A61P 3/10
For glucose homeostasis: for hyperglycaemia, e.g. antidiabetics
A61P 7/02
Drugs for disorders of the blood or the extracellular fluid: antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
A61P 7/04
Drugs for disorders of the blood or the extracellular fluid: antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents