Methods and compositions for delivering active agents with enhanced pharmacological properties
AssigneeDuke University
InventorAshutosh Chilkoti
Life of this patent
Estimating the term…
Abstract
Provided herein are methods of enhancing in vivo efficacy of an active agent, comprising: administering to a subject an active agent that is coupled to a bioelastic polymer or elastin-like peptide, wherein the in vivo efficacy of the active agent is enhanced as compared to the same active agent when administered to the subject not coupled to (or not associated with) a bioelastic polymer or ELP.
Claims13
A method of administering to a subject a chemotherapeutical agent conjugated to an elastin-like peptide (ELP) via a linker at the C-terminus, wherein the chemotherapeutical agent is conjugated to the ELP, wherein the subject is not subjected to hyperthermia,
- wherein the conjugate is administered systemically, and is formulated for weekly administration.
Dependencies are inferred from the claim text.