Campylobacter vaccine
AssigneeThe Governors of the University of Alberta
InventorsChristine Szymanski, Harald Nothaft
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Abstract
The present application provides a vaccine composition comprising: bacteria engineered to express at least one N-glycan of Campylobacter, such as C. jejuni for example, or an N-glycan derivative thereof on its cell surface; and one or more of a physiologically acceptable diluent, excipient, adjuvant or carrier. The bacteria is Escherichia coli, Salmonella or any suitable bacteria that offers sufficient expression and improved immunogenic response. The vaccine composition can be formulated for administration to animals, such as poultry, including chickens.
Claims12
A method of vaccinating an animal against Campylobacter, the method comprising:
- administering to an animal a vaccine composition comprising:
- E. coli engineered with a Campylobacter pgl operon lacking a functional pglB gene to express at least one N-glycan of Campylobacter or an N-glycan derivative thereof on its cell surface;
- and one or more of a physiologically acceptable diluent, excipient, adjuvant or carrier, wherein the E. coli is engineered to be partially or fully deficient in the expression of O-antigen, and wherein the N-glycan is expressed on the surface of E. coli as a Lipid A core fusion.
Dependencies are inferred from the claim text.