Polypeptide vaccine
AssigneeAgency for Science, Technology and Research
InventorQi Zeng
Life of this patent
Estimating the term…
Abstract
We provide a polypeptide vaccine for treatment and prevention of cancer, particularly prevention of metastasis of cancer. Also provided are methods of treating or preventing cancer, and pharmaceutical compositions comprising the polypeptide vaccine.
Claims23
A method for the treatment of cancer, the method comprising administering to a patient in need thereof a therapeutically effective amount of a polypeptide, wherein the polypeptide comprises:
- a) a first fragment of Phosphatase of Regenerating Liver 3 (PRL3) consisting of the amino acid sequence EVTYDKTPLEKDGITV (amino acids 1 to 16 of SEQ ID NO:18);
- b) a linker peptide;
- and
- c) a second fragment of PRL3 consisting of the amino acid sequence DPHTHKTRC (amino acids 21 to 29 of SEQ ID NO:18);
- wherein the linker peptide is situated between the first and second fragment of PRL3;
- and
- wherein the polypeptide stimulates the production of anti-PRL3 anti-cancer antibodies in the patient thereby inhibiting cancer metastasis.
A method for inhibiting metastasis in a patient with a Phosphatase of Regenerating Liver 3 (PRL3) expressing cancer, the method comprising:
- a) identifying PRL3 expression in a patient's cancer;
- and
- b) administering a polypeptide which comprises:
- i) a first fragment of Phosphatase of Regenerating Liver 3 (PRL3) consisting of the amino acid sequence EVTYDKTPLEKDGITV (amino acids 1 to 16 of SEQ ID NO:18);
- ii) a linker peptide;
- and
- iii) a second fragment of PRL3 consisting of the amino acid sequence DPHTHKTRC (amino acids 21 to 29 of SEQ ID NO:18);
- wherein the linker peptide is situated between the first and second fragment of PRL3;
- and
- wherein the patient is induced to produce anti-PRL3 anti-cancer antibodies, thereby inhibiting cancer metastasis.
A method for treating cancer in a person, the method comprising:
- a) determining whether a person is suffering from a cancer associated with Phosphatase of Regenerating Liver 3 (PRL3);
- and
- b) administering to that person a polypeptide which comprises:
- i) a first fragment of Phosphatase of Regenerating Liver 3 (PRL3) consisting of the amino acid sequence EVTYDKTPLEKDGITV (amino acids 1 to 16 of SEQ ID NO:18);
- ii) a linker peptide;
- and
- iii) a second fragment of PRL3 consisting of the amino acid sequence DPHTHKTRC (amino acids 21 to 29 of SEQ ID NO:18);
- wherein the linker peptide is situated between the first and second fragment of PRL3;
- and
- wherein the patient is induced to produce anti-PRL3 anti-cancer antibodies, thereby inhibiting cancer metastasis.
A method of cancer vaccination, the method comprising administering to a patient a polypeptide which comprises:
- a) a first fragment of Phosphatase of Regenerating Liver 3 (PRL3) consisting of the amino acid sequence EVTYDKTPLEKDGITV (amino acids 1 to 16 of SEQ ID NO:18);
- b) a linker peptide;
- and
- c) a second fragment of PRL3 consisting of the amino acid sequence DPHTHKTRC (amino acids 21 to 29 of SEQ ID NO:18);
- wherein the linker peptide is situated between the first and second fragment of PRL3;
- and wherein the polypeptide stimulates the production of anti-PRL3 anti-cancer antibodies in the patient.
Dependencies are inferred from the claim text.