Nanoparticles comprising aminoacyl tRNA synthetase and anticancer composition comprising same
AssigneeMedicinal Bioconvergence Research Center
InventorsSunghoon Kim, Min Chul Park
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Abstract
The present invention relates to nanoparticles comprising aminoacyl tRNA synthetase and an anticancer composition comprising the same and, specifically, to nanoparticles which comprise glycyl-tRNA synthetase (GRS), leucyl-tRNA synthetase (LRS), and isoleucyl-tRNA synthetase (IRS), and have anticancer or immunostimulating activity; a pharmaceutical composition for preventing or treating cancer, comprising the nanoparticles as an active ingredient; a composition for immunostimulation; and a method for preparing the nanoparticles.
Claims11
A method for treating cancer or enhancing immune function in a subject, the method comprising administering an effective amount of nanoparticles to a subject in need of treating cancer or enhancing immune function,
- wherein the nanoparticles comprise glycyl-tRNA synthetase (GRS), leucyl-tRNA synthetase (LRS), and isoleucyl-tRNA synthetase (IRS),
- wherein the GRS comprises an amino acid sequence of SEQ ID NO:
- 1 and the 390th amino acid cysteine in the amino acid sequence of SEQ ID NO:
- 1 is palmitoylated.
Dependencies are inferred from the claim text.