Microstructure for capturing and releasing microorganism
AssigneeQuantamatrix Inc.
InventorYong Gyun Jung
Life of this patent
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Abstract
Provided is a method for capture and release of microorganisms using microstructures. The method includes providing microstructures coated with a protein for attachment/detachment of microorganisms, mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution, stirring the mixed solution to attach the microorganisms to the microstructures, separating the microorganism-attached microstructures from the mixed solution; and exposing the microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration to detach the microorganisms from the microstructures.
Claims13
A structure for capture and release of microorganisms, comprising:
- a microstructure,
- wherein the microstructure includes a protective layer and the protective layer is a silica-coated layer;
- and
- a protein coated on the microstructure with the protein directly contacting the microstructure, wherein the protein is capable of attaching and detaching the microorganisms,
- wherein the protein is a calcium-dependent serum protein,
- wherein the microstructure supports the protein coated on the microstructure and the microorganisms attached and detached to the protein.
A method for capture and release of microorganisms using microstructures, comprising:
- providing microstructures;
- wherein the microstructures include a protective layer and the protective layer is a silica-coated layer;
- directly contacting a protein to the microstructures, wherein the protein is capable of attaching and detaching microorganisms,
- wherein the protein is a calcium-dependent serum protein,
- wherein the microstructures support the protein coated on the microstructures and the microorganisms attached and detached to the protein;
- mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution;
- stirring the mixed solution to attach the microorganisms to the microstructures;
- separating the microorganism-attached microstructures from the mixed solution;
- and
- exposing the microorganism-attached microstructures to an environment where the substances assisting in attachment of the microorganisms are present at a low concentration such that the microorganisms are detached from the microstructures due to the low concentration of the substances, and
- wherein the substances assisting in the attachment and detachment of the microorganisms are calcium ions.
A method for capture and release of microorganisms using microstructures, comprising:
- providing microstructures,
- wherein the microstructures include a protective layer and the protective layers is a silica-coated layer;
- directly contacting a protein to the microstructures, wherein the protein is capable of attaching and detaching microorganisms,
- wherein the protein is a calcium-dependent serum protein,
- wherein the microstructures support the protein coated on the microstructures and the microorganisms attached and detached to the protein;
- mixing the microstructures with a solution containing substances assisting in attachment of microorganisms in a solution containing microorganisms to prepare a mixed solution;
- stirring the mixed solution to attach the microorganisms to the microstructures;
- separating the microorganism-attached microstructures from the mixed solution;
- and
- exposing the microorganism-attached microstructures to an environment free of the substances used in assisting the attachment of the microorganisms such that the microorganisms are detached from the microstructures, and
- wherein the substances assisting in the attachment and detachment of the microorganisms are calcium ions.
Dependencies are inferred from the claim text.