Adapted rhinovirus C
AssigneeWisconsin Alumni Research Foundation
InventorsYury A. Bochkov, James E. Gern, Ann C. Palmenberg, Kelly E. Watters
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Abstract
A mutated rhinovirus C, methods of creating and methods of propagating thereof, wherein the mutated rhinovirus shows enhanced virus yields after infection and induced visible cytopathic effect.
Claims16
An isolated mutated rhinovirus C, wherein the mutation is E41K in rhinovirus C protein 3A or a mutation in the amino acid at a positional equivalent of E41 in protein 3A to K in non-C15 strains.
A method of creating a mutated rhinovirus C, wherein the method comprises the steps of introducing E41K in rhinovirus C protein 3A of strain C15 or a mutation that is a positional equivalent of E41K in non-C15 strains, and isolating the mutated rhinovirus C.
Dependencies are inferred from the claim text.