Synthetic membrane-receiver complexes
AssigneeRubius Therapeutics, Inc.
InventorsAvak Kahvejian, Jordi Mata-Fink, John Round, David Arthur Berry, Noubar B. Afeyan
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Abstract
Compositions comprising synthetic membrane-receiver complexes, methods of generating synthetic membrane-receiver complexes, and methods of treating or preventing diseases, disorders or conditions therewith.
Claims24
A method of reducing phenylalanine concentration in the blood of a subject, comprising administering to the subject a pharmaceutical composition comprising a plurality of enucleated erythroid cells comprising at least 1,000 copies of an exogenous polypeptide comprising phenylalanine ammonia lyase (PAL), wherein the exogenous polypeptide is not fused to an endogenous polypeptide and is intracellular, wherein each of the enucleated erythroid cells of said plurality was made by a process comprising introducing into an erythroid cell precursor an exogenous nucleic acid encoding the exogenous polypeptide, and wherein none of the enucleated erythroid cells of said plurality is hypotonically loaded.
Dependencies are inferred from the claim text.