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US 10,253,091 B2Granted
Antibody constant region variant
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki Igawa, Taichi Kuramochi, Atsuhiko Maeda, Hirotake Shiraiwa
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AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsTomoyuki Igawa, Taichi Kuramochi, Atsuhiko Maeda, Hirotake Shiraiwa
Estimating the term…
By altering amino acid sequences, the present inventors successfully produced constant regions that can confer antibodies with particularly favorable properties for pharmaceutical agents. When used to produce antibodies, the altered constant regions produced according to the present invention significantly reduce heterogeneity. Specifically, the antibody homogeneity can be achieved by using antibody heavy chain and light chain constant regions introduced with alterations provided by the present invention. More specifically, the alterations can prevent the loss of homogeneity of antibody molecules due to disulfide bond differences in the heavy chain. Furthermore, in a preferred embodiment, the present invention can improve antibody pharmacokinetics as well as prevent the loss of homogeneity due to C-terminal deletion in antibody constant region.
A human κ chain constant region variant comprising the amino acid sequence of SEQ ID NO:
A human κ chain constant region variant comprising the amino acid sequence of SEQ ID NO:
A human κ chain constant region variant that is 102-107 amino acid residues in length, comprises at least one Cys residue at a position or positions selected from positions 102-106, and does not comprise a Cys residue at position 107, wherein the variant comprises SEQ ID NO:
Dependencies are inferred from the claim text.