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US 10,253,089 B2Granted
Matrix metalloproteinase cleavable protein polymers for cancer gene therapy
AssigneeUniversity of Utah Research Foundation
InventorsHamidreza Ghandehari, Joseph Cappello, Jordan Frandsen, Joshua Gustafson, Khaled Greish, Robert Andrew Price
Life of this patent
Estimating the term…
Abstract
A delivery system that includes a recombinantly synthesized protein polymer with protease cleavage sites such as matrix metalloproteinase responsive sequences engineered within the protein polymer. The system may be used to treat cancer, wounds, or pathological conditions in other tissues that express excess protease relative to healthy tissue.
Claims9
A protein polymer, wherein the protein polymer has the structure:
- [GAGS(GAGAGS)2(GVGVP)3GVGGPQGIFGQPGKGVP(GVGVP)11 (GAGAGS)5GA]6 (SEQ ID NO:
- 16), and wherein the protein polymer is produced using recombinant methods.
Dependencies are inferred from the claim text.