Prophylactic vaccine against egg drop syndrome (EDS)
AssigneeKM Biologics Co., Ltd.
InventorsKenichi Yamazaki, Kiyohiko Andoh, Ryuichi Sakamoto, Kiyotaka Suenaga, Takeshi Arakawa, Hirotaka Uefuji, Tetsuya Harakuni, Takeshi Miyata
Life of this patent
Estimating the term…
Abstract
The present invention is intended to provide an egg drop syndrome (EDS) vaccine that is capable of effectively preventing EDS and can be stably supplied. The EDS vaccine provided to this end contains as an active ingredient fused protein in which a polypeptide having a coiled-coil forming unit is bound to the knob region in the fiber protein of EDS virus (EDSV).
Claims30
A fused protein in which a polypeptide having a coiled-coil forming unit is bound to a Knob region in a fiber protein of egg drop syndrome (EDS) virus EDSV), wherein said coiled-coil forming unit is derived from a native multimer-forming protein and said native multimer-forming protein is a GCN4 or a cartilage matrix protein (CMP) and wherein:
- when said native multimer-forming protein is a GCN4 the Knob comprises a polypeptide consisting of an amino acid sequence represented by SEQ ID NO:
- 11 or a polypeptide having at least 95% homology to the amino acid sequence of SEQ ID NO:11;
- and
- when said native multimer-forming protein is a CMP the Knob comprises polypeptide consisting of an amino acid sequence represented by SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.