Biocompatible, biomimetic ampholyte materials
AssigneeBioInteractions Ltd.
InventorsFanny Burrows, John E. Mckendrick, Alan Rhodes, Simon J. Onis, Shivpal S. Sandhu
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Abstract
New ampholyte biomaterial compounds containing ampholyte moieties are synthesized and integrated into polymeric assemblies to provide hydrophilic polymers exhibiting improved biocompatibility, haemocompatibility, hydrophilicity non-thrombogenicity, anti-bacterial ability, and mechanical strength, as well as suitability as a drug delivery platform.
Claims13
A compound comprising a polymer that comprises a polymer backbone and an ampholyte compound pendant group, with said compound being represented by a general formula:
- wherein POLY represents the polymer backbone,
- wherein Y represents an oxygen in an ester moiety or a secondary amine in an amide moiety,
- wherein m and p independently range from 0 to 6, with an m of 1 to 6 denoting a hydrocarbon chain referred to as the m-hydrocarbon chain and a p in a range from 1 to 6 denoting a hydrocarbon chain referred to as the p-hydrocarbon chain,
- wherein n is at least one and indicates a number of pendant groups that are independently selected and independently attached to the polymer backbone, and
- wherein R1 is hydrophilic and chosen from the group consisting of (a) a substituted alkyl group, (b) a substituted cycloalkyl group, (c) a substituted cycloalkenyl group, (d) a substituted or unsubstituted heterocycle group, and (e) a substituted alkenyl group, wherein the R1 group terminates with a methoxy group;
- wherein R2 and R3, are independently chosen from the group consisting of
- (a) a substituted or unsubstituted alkyl group, (b) a substituted or unsubstituted aryl group,(c) a substituted or unsubstituted cycloalkyl group, (d) a substituted or unsubstituted cycloalkenyl group, (e) a substituted or unsubstituted heterocycle group, and (f) a substituted or unsubstituted alkenyl group;
- and
- wherein the m-hydrocarbon chain and/or the p-hydrocarbon chain are substituted or unsubstituted hydrocarbon chains, wherein if the hydrocarbon chain is substituted substitution is an attachment to the hydrocarbon chain or is a heteroatom within the hydrocarbon chain.
A polymer comprising a polymerization product of an ampholyte monomer represented by a general formula (i):
- wherein R1 is hydrophilic and chosen from the group consisting of (a) a substituted alkyl group, (b) a substituted cycloalkyl group, (c) a substituted cycloalkenyl group, (d) a substituted or unsubstituted heterocycle group, and (e) a substituted alkenyl group, wherein the R1 group terminates with a methoxy group;
- wherein R2 and R3, are independently chosen from the group consisting of
- (a) a substituted or unsubstituted alkyl group, (b) a substituted or unsubstituted aryl group, (c) a substituted or unsubstituted cycloalkyl group, (d) a substituted or unsubstituted cycloalkenyl group, (e) a substituted or unsubstituted heterocycle group, and (f) a substituted or unsubstituted alkenyl group;
- wherein m and p independently range from 0 to 6, with an m of 1 to 6 denoting a hydrocarbon chain referred to as the m-hydrocarbon chain and a p in a range from 1 to 6 denoting a hydrocarbon chain referred to as the p-hydrocarbon chain;
- wherein the m-hydrocarbon chain and/or the p-hydrocarbon chain are substituted or unsubstituted hydrocarbon chains, wherein if the hydrocarbon chain is substituted substitution is an attachment to the hydrocarbon chain or is a heteroatom within the hydrocarbon chain;
- and
- wherein Z represents a polymerizable group comprising a vinylic or allylic group that is capable of undergoing free radical polymerization.
Dependencies are inferred from the claim text.