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AssigneeZoetis Services LLC
InventorsJacqueline Gayle Marx, John Morgan Hardham, Paul J. Dominowski, Vicki Jon Rapp Gabrielson, Monica Balasch Sanuy, Marta Cabana Sumsi, Laia Plaja Dilmé, Alicia Urniza Hostench, Oscar Romero Galindo
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The present invention is directed to novel immunogenic compositions that protect swine from disease caused by porcine epidemic diarrhea virus (PEDV). The present invention is also directed to novel immunogenic compositions that protect swine from disease caused by porcine deltacoronavirus (PDCoV), alone or as combination vaccine to protect against PEDV. The compositions of the invention provide killed viruses whose effectiveness is enhanced by the selection of preferred adjuvants. Novel culture methods are also employed to increase reproducible yield of cultured viruses. Live vaccines are also provided from the Calaf14 PEDV isolate.
A method of producing a neutralizing antibody response against PEDV in a subject swine comprising administering to the subject an immunogenic composition comprising inactivated porcine epidemic diarrhea virus (PEDV), adjuvanted in a stabilized oil-in-water emulsion of lecithin and mineral oil also containing aluminum hydroxide, in an amount and duration effective to produce the neutralizing antibody response.
A method of producing a neutralizing antibody response against porcine deltacoronavirus (PDCoV) in a subject swine, comprising administering to the subject the immunogenic composition comprising both inactivated porcine epidemic diarrhea virus (PEDV) and inactivated porcine deltacoronavirus (PDCoV), adjuvanted as an oil-in-water emulsion, wherein the adjuvant components include Amphigen® and aluminum hydroxide, in an amount and duration effective to produce the neutralizing antibody response against PDCoV.
Dependencies are inferred from the claim text.