# US 10,246,672 B2 · Nanolipids with encapsulated alcohol > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 10,246,672 B2 - Document ID: US10246672B2 - Status: Granted - Kind: B2 - Application number: 15/673,603 - Filed: 2017-08-10 - Published: 2017-11-23 - Granted: 2019-04-02 - Earliest claimed: 2005-12-30 - Assignees: NuVessl, Inc. - Applicants: NuVessl, Inc. - Inventors: Michael W. Fountain - Web page: https://patentgrep.com/patent/US10246672B2 ## CPC - C12G 3/00: Preparation of other alcoholic beverages - A23G 9/32: characterised by the composition {containing organic or inorganic compounds} - A23G 9/48: Composite products, e.g. layered {, laminated}, coated, filled - A23G 9/485: {hollow products, e.g. with inedible or edible filling, fixed or movable within the cavity} - A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21) - A23P 10/35: with oils, lipids, monoglycerides or diglycerides - A61K 9/51: Nanocapsules; {Nanoparticles; (nanotubes A61K9/0092; polymeric micelles A61K9/1075; polymersomes A61K9/1273; pure drug nanoparticles A61K9/14; drug nanoparticles with adsorbed surface modifiers A61K9/141; conjugates, e.g. between drug and non-active nanoparticles, A61K47/50; preparations for in vivo diagnosis A61K49/00; with radioactive substances A61K51/00)} - A61K 9/5123: {Organic compounds, e.g. fats, sugars} - A61K 9/5192: {Processes} - C12G 3/04: by mixing, e.g. for preparation of liqueurs - C12G 3/05: with health-improving ingredients, e.g. flavonoids, flavones, polyphenols or polysaccharides - A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs - C12G: WINE; PREPARATION THEREOF; ALCOHOLIC BEVERAGES (beer C12C); PREPARATION OF ALCOHOLIC BEVERAGES NOT PROVIDED FOR IN SUBCLASSES C12C OR C12H - A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF - A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B) - A23P: SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION ## Abstract A method for preparing ethanol-containing nanolipid particles, which can be used in food products, frozen desserts, or beverages. The method comprises nanolipidic vehicles in which ethanol-containing substances are encapsulated, said ethanol-containing nanolipidic vehicles can be combined with food products, desserts or beverage ingredients including those that are subsequently frozen. The food product, dessert or beverage can remain in a frozen state during consumption by an individual. A composition comprising ethanol-containing nanolipid particles, which can be used in food products, frozen desserts, or beverages. ## Claims ### Claim 1 An ethanol-loaded nanolipid particle (NLP) carrier made by a process comprising the steps of: a) providing a monophasic optically clear precursor stock having phospholipids solubilized in ethanol and water; b) diluting said precursor stock with an ethanol solvent to produce a solvent-diluted precursor stock, wherein said diluting of said precursor stock with said ethanol solvent is at a ratio ranging from about 1 part precursor stock to about 20 parts ethanol solvent (volume/volume) to a ratio ranging from about 1 part precursor stock to about 0.3 parts ethanol solvent (volume/volume), said diluting of said precursor stock resulting in one or more substantially unloaded nanolipid particle (NLP), wherein the more ethanol solvent used for said diluting of the precursor stock, the smaller the nanolipids particles will be; c) adding an ethanol-containing substance suitable for human consumption to an aqueous solvent to produce an aqueous-ethanol monophase; and d) combining said solvent-diluted precursor stock formed in step (b) with said aqueous-ethanol monophase from step (c), wherein said one or more substantially unloaded nanolipid particle (NLP) formed in step (b) becomes loaded with the ethanol-containing substance from step (c) as a passenger in the nanolipid particle (NLP) resulting in one or more ethanol-loaded NLP carrier sized from 20 nm to 300 nm. ### Claim 2 (depends on 1) The nanolipid particle (NLP) carrier of claim 1, wherein said ethanol-containing substance suitable for human consumption is an ethanol-containing beverage product. ### Claim 3 (depends on 1) The nanolipid particle (NLP) carrier of claim 1, wherein, said aqueous-ethanol monophase comprises from 12.5% ethanol in water (volume/volume) to 50% ethanol in water (volume/volume). ### Claim 4 (depends on 3) The nanolipid particle (NLP) carrier of claim 3, wherein said aqueous-ethanol monophase comprises from 15% ethanol in water (volume/volume) to 35% ethanol in water (volume/volume). ### Claim 5 (depends on 1) The nanolipid particle (NLP) carrier of claim 1, wherein said precursor stock comprises phospholipids selected from the group consisting of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylinositol (PI), and mixtures thereof. ### Claim 6 (depends on 1) The nanolipid particle (NLP) carrier of claim 1, wherein one or more lipophilic or amphipathic passenger molecules are added to the precursor stock prior to dilution with said ethanol solvent in step (b). ### Claim 7 (depends on 1) The nanolipid particle (NLP) carrier of claim 1, wherein an additional water-soluble passenger molecule is added to the aqueous solvent prior to adding the ethanol-containing substance. ### Claim 8 (depends on 1) The nanolipid particle (NLP) carrier of claim 1, wherein said ethanol loaded NLP carriers formed by combining said solvent-diluted precursor stock with said aqueous-ethanol monophase remain stably sized when frozen by a commercially acceptable process for consumption while frozen. ### Claim 9 An ethanol-loaded nanolipid particle (NLP) carrier made by a process comprising the steps of: a) providing a monophasic optically clear precursor stock having phospholipids solubilized in ethanol and water; b) diluting said precursor stock with an ethanol solvent to produce a solvent-diluted precursor stock, wherein said diluting of said precursor stock with said ethanol solvent is at a ratio ranging from about 1 part precursor stock to about 20 parts ethanol solvent (volume/volume) to a ratio ranging from about 1 part precursor stock to about 0.3 parts ethanol solvent (volume/volume), said diluting of said precursor stock resulting in one or more substantially unloaded nanolipid particle (NLP), wherein the more ethanol solvent used for said diluting of the precursor stock, the smaller the nanolipid particles will be; c) adding an ethanol-containing substance for human consumption to an aqueous solvent to produce an aqueous-ethanol monophase, said aqueous-ethanol monophase comprising from 12.5% ethanol in water (volume/volume) to 50% ethanol in water (volume/volume); and d) combining said solvent-diluted precursor stock formed in step (b) with said aqueous-ethanol monophase from step (c), wherein said one or more substantially unloaded nanolipid particle (NLP) formed in step (b) becomes loaded with the ethanol-containing substance from step (c) as a passenger in the nanolipid particle (NLP). ### Claim 10 (depends on 9) The nanolipid particle (NLP) carrier of claim 9, wherein said ethanol-loaded nanolipid particle (NLP) carriers are sized from 20 nm-300 nm. ### Claim 11 (depends on 9) The nanolipid particle (NLP) carrier of claim 9, wherein said ethanol loaded NLP carriers formed by combining said solvent-diluted precursor stock with said aqueous-ethanol monophase remain stably sized when frozen by a commercially acceptable process for consumption while frozen. ### Claim 12 (depends on 9) The nanolipid particle (NLP) carrier of claim 9, wherein one or more lipophilic or amphipathic passenger molecules are added to the precursor stock prior to dilution with said ethanol solvent in step (b). ### Claim 13 (depends on 9) The nanolipid particle (NLP) carrier of claim 9, wherein an additional water-soluble passenger molecule is added to the aqueous solvent. ### Claim 14 (depends on 9) The nanolipid particle (NLP) carrier of claim 9, wherein said precursor stock comprises phospholipids selected from the group consisting of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylinositol (PI), and mixtures thereof. ### Claim 15 An ethanol-loaded nanolipid particle (NLP) carrier made by a process comprising the steps of: a) providing a monophasic optically clear precursor stock having phospholipids solubilized in ethanol and water; b) diluting said precursor stock with an ethanol solvent to produce a solvent-diluted precursor stock, wherein said diluting of said precursor stock with said ethanol solvent is at a ratio ranging from about 1 part precursor stock to about 20 parts ethanol solvent (volume/volume) to a ratio ranging from about 1 part precursor stock to about 0.3 parts ethanol solvent (volume/volume), said diluting of said precursor stock resulting in one or more substantially unloaded nanolipid particle (NLP), wherein the more ethanol solvent used for said diluting of the precursor stock, the smaller the nanolipid particles will be; c) adding an ethanol-containing substance for human consumption to an aqueous solvent to produce an aqueous-ethanol monophase, said aqueous-ethanol monophase comprising from 15% ethanol in water (volume/volume) to 35% ethanol in water (volume/volume); and d) combining said solvent-diluted precursor stock formed in step (b) with said aqueous-ethanol monophase from step (c), wherein said one or more substantially unloaded nanolipid particle (NLP) formed in step (b) becomes loaded with the ethanol-containing substance from step (c) as a passenger in the nanolipid particle (NLP), said ethanol-loaded nanolipid particle (NLP) carriers are sized from 20 nm-300 nm. ### Claim 16 (depends on 15) The nanolipid particle (NLP) carrier of claim 15, wherein said ethanol loaded NLP carriers formed by combining said solvent-diluted precursor stock with said aqueous-ethanol monophase remain stably sized when frozen by a commercially acceptable process for consumption while frozen. ### Claim 17 (depends on 15) The nanolipid particle (NLP) carrier of claim 15, wherein one or more lipophilic or amphipathic passenger molecules are added to the precursor stock prior to dilution with said ethanol solvent in step (b). ### Claim 18 (depends on 15) The nanolipid particle (NLP) carrier of claim 15, wherein an additional water-soluble passenger molecule is added to the aqueous solvent prior to adding the ethanol-containing substance. ### Claim 19 (depends on 15) The nanolipid particle (NLP) carrier of claim 15, wherein said precursor stock comprises phospholipids selected from the group consisting of phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA), phosphatidylinositol (PI), and mixtures thereof.