# US 10,246,444 B2 · 1,2-dithiolane and dithiol compounds useful in treating mutant EGFR-mediated diseases and conditions

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,246,444 B2
- Document ID: US10246444B2
- Status: Granted
- Kind: B2
- Application number: 15/873,255
- Filed: 2018-01-17
- Published: 2018-07-26
- Granted: 2019-04-02
- Earliest claimed: 2017-01-21
- Assignees: Sabila Biosciences LLC
- Applicants: Sabila Biosciences LLC
- Inventors: Tarek Suhayl Mansour
- Web page: https://patentgrep.com/patent/US10246444B2

## CPC

- C07D 409/12: linked by a chain containing hetero atoms as chain links
- A61P 35/00: Antineoplastic agents
- C07D 215/44: with aryl radicals attached to said nitrogen atoms
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 409/14: containing three or more hetero rings
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compositions of the invention comprise 1,2-dithiolane, dithiol and related compounds useful as therapeutic agents for the treatment and prevention of diseases and conditions associated with aberrant EGFR activity.

## Claims

### Claim 1

A compound having formula (I):
including enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, wherein:
A is selected from the group consisting of
with the proviso that when A is
then Y cannot be N and X2 cannot be H when Y is N;
Z1 is selected from the group consisting of S, SO, and SO2;
Z2 is selected from the group consisting of S, SO, and SO2;
Z3 is selected from the group consisting of SH, SCOR1, SO2R2, and SO3H;
Z4 is selected from the group consisting of SH, SCOR1, SO2R2, and SO3H;
n=0, 1, 2, 3, 4;
W is selected from the group consisting of CO and SO2;
X1 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and, optionally substituted C1-6 alkoxy;
X2 is selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, OR3,
and the C2-6 sugar alcohols such as ethylene glycol, glycerol, erythritol, threitol, arabitol, xylitol, ribitol, mannitol, galacitol frucitol, iditol, inositol, and sorbitol;
Y is selected from the group consisting of N and C—CN;
R is at each occurrence independently selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, halogen, C1-6 haloalkyl, C3-7 cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocyclyl, heterocyclylalkyl, heteroaryl, heteroarylalkyl, alkoxyheteroarylalkyl,
R1a is at each occurrence independently selected from the group consisting of hydrogen, halogen, C1-6 alkyl, and C1-6 alkoxy;
R1 is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy;
R2 is at each occurrence independently selected from the group consisting of hydrogen, optionally substituted C1-6 alkyl, and optionally substituted C1-6 alkoxy;
R3 is an optionally substituted C1-6 alkyl;
R4 is at each occurrence independently selected from the group consisting of hydrogen, OH, and OR5;
q=0, 1, 2, 3, 4, or 5;
R5 is at each occurrence an optionally substituted C1-6 alkyl;
two R5 substituents can be joined together with the atoms to which they are bound to form a 5 to 6 membered ring.

### Claim 2 (depends on 1)

The compound according to claim 1 having formula (II):
including enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.

### Claim 3 (depends on 1)

The compound according to claim 1 having formula (III):
including pharmaceutically acceptable salts thereof.

### Claim 4 (depends on 1)

The compound according to claim 1 having formula (IV):
including enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.

### Claim 5 (depends on 1)

The compound according to claim 1 having formula (V):
including pharmaceutically acceptable salts thereof.

### Claim 6 (depends on 1)

The compound according to claim 1 having formula (VI):
including pharmaceutically acceptable salts thereof.

### Claim 7 (depends on 1)

The compound according to claim 1 having formula (VII):
including pharmaceutically acceptable salts thereof.

### Claim 8 (depends on 1)

The compound according to claim 1 having formula (VIII):
including enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.

### Claim 9 (depends on 1)

The compound according to claim 1 having formula (IX):
Including pharmaceutically acceptable salts thereof.

### Claim 10 (depends on 1)

The compound according to claim 1 that is:
S,S′-(2-((4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)carbamoyl)propane-1,3-diyl)diethanethioate;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-mercapto-2-(mercaptomethyl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-3-carboxamide;
S,S′-(2-((4-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)carbomoyl)propane-1,3-diyl)diethanethioate;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-mercapto-2-(mercaptomethyl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-(3-chloro-4-fluorophenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide;
N-(4-(3-chloro-4-((3-fluorobenzyloxy)phenylamino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetroxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2,2-tetroxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide 1-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide 1,1-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-3-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,1-dioxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(2,2-dioxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,2-dithiolan-4-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)ethane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-4-yl)ethane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetroxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2,2-tetroxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-5-(1,2-dithiolan-4-yl)pentanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1,1-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-3-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,1-dioxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2,2-dioxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-4-yl)methanesulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)ethane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-4-yl)ethane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetraoxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,1,2,2-tetraoxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-4-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-4-yl)butanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1-oxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(2-oxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2-dioxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,1-dioxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(2,2-dioxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,1,2-trioxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,2,2-trioxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-5-(1,1,2,2-tetraoxido-1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-4-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1,2-dithiolane-3-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(2-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(1,1-dioxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-1-(2,2-dioxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-3-yl)ethanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-2-(1,2-dithiolan-4-yl)ethanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,2-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2-trioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-carboxamide 1,1,2,2-tetroxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2,2-trioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,1,2,2-tetroxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-5-(1,2-dithiolan-3-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-4-yl)pentanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-4-sulfonamide 1,1-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1,2-dithiolane-3-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2-oxido-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,1-dioxo-1,2-dithiolan-3-yl)methanesulfonamide
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(2,2-dioxo-1,2-dithiolan-3-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-1-(1,2-dithiolan-4-yl)methanesulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-3-yl)ethane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-2-(1,2-dithiolan-4-yl)ethane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-3-(1,2-dithiolan-4-yl)propane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-3-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-ethoxyquinazolin-6-yl)-4-(1,2-dithiolan-4-yl)butane-1-sulfonamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -1-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -1,1-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -2-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -2,2-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -1-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -1,1-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -2-oxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -2,2-dioxide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-fluorophenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -1-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -1,1-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -2-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-1,2-dithiolane-3-carboxamide -2,2-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-3-cyano-7-(2,3-dihydroxypropoxy)quinolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -1-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -1,1-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -2-oxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-1,2-dithiolane-3-carboxamide -2,2-dioxide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2-oxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(1,1-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-2-(2,2-dioxido-1,2-dithiolan-3-yl)acetamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2-oxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(1,1-dioxido-1,2-dithiolan-3-yl)propanamide;
N-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-7-(2,3-dihydroxypropoxy)quinazolin-6-yl)-3-(2,2-dioxido-1,2-dithiolan-3-yl)propanamide;
or a pharmaceutically acceptable form thereof.

### Claim 11 (depends on 1)

A composition comprising an effective mutant EGFR modulating amount of at least one compound according to claim 1.

### Claim 12 (depends on 11)

The composition according to claim 11, further comprising at least one excipient.