# US 10,246,436 B2 · 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same

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- Number: US 10,246,436 B2
- Document ID: US10246436B2
- Status: Granted
- Kind: B2
- Application number: 15/252,112
- Filed: 2016-08-30
- Published: 2017-07-27
- Granted: 2019-04-02
- Earliest claimed: 2015-09-02
- Assignees: Trevena, Inc.
- Applicants: Trevena, Inc.
- Inventors: Aimee Crombie Speerschneider; Dennis Shinji Yamashita; Philip Michael Pitis; Michael John Hawkins; Guodong Liu; Tamara Ann Miskowski Daubert; Catherine C. K. Yuan; Robert Borbo Kargbo; Robert Jason Herr; Donna Romero; Gregory J. Pacofsky
- Web page: https://patentgrep.com/patent/US10246436B2

## CPC

- C07D 401/12: linked by a chain containing hetero atoms as chain links
- A61K 31/445: Non condensed piperidines, e.g. piperocaine
- A61P 13/10: of the bladder
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/06: Antimigraine agents
- A61P 25/16: Anti-Parkinson drugs
- A61P 25/22: Anxiolytics
- A61P 25/24: Antidepressants
- A61P 25/30: for treating abuse or dependence
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 211/22: by oxygen atoms
- C07D 241/04: having no double bonds between ring members or between ring members and non-ring members
- C07D 401/14: containing three or more hetero rings
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 405/14: containing three or more hetero rings
- C07D 451/02: containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present embodiments are directed, in part, to compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof for modulating the activity of delta opioid receptor, biased and/or unbiased, and/or methods for treating pain, migraines, headaches, depression, Parkinsons Disease, anxiety, and/or overactive bladder, and other disorders and conditions described herein or any combination thereof.

## Claims

### Claim 1

A compound having the formula of:
or a pharmaceutically acceptable salt thereof.

### Claim 2

A compound having the formula of
or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, of claim 1.

### Claim 4 (depends on 2)

A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, of claim 2.

### Claim 5 (depends on 1)

A method of treating a migraine in a subject comprising administering to the subject the compound of claim 1, or a pharmaceutically acceptable salt thereof.

### Claim 6 (depends on 2)

A method of treating a migraine in a subject comprising administering to the subject the compound of claim 2, or a pharmaceutically acceptable salt thereof.

### Claim 7 (depends on 3)

A method of treating a migraine in a subject comprising administering to the subject the pharmaceutical composition of claim 3.

### Claim 8 (depends on 4)

A method of treating a migraine in a subject comprising administering to the subject the pharmaceutical composition of claim 4.

### Claim 9 (depends on 8)

The method of claim 8, wherein the subject is a subject in need thereof.

### Claim 10 (depends on 7)

The method of claim 7, where in the subject is a subject in need thereof.

### Claim 11 (depends on 5)

The method of claim 5, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 12 (depends on 6)

The method of claim 6, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 13 (depends on 7)

The method of claim 7, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 14 (depends on 8)

The method of claim 8, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 15 (depends on 1)

The compound of claim 1, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 16 (depends on 2)

The compound of claim 2, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 17 (depends on 3)

The pharmaceutical composition of claim 3, wherein the pharmaceutically acceptable salt is a hydrochloride salt.

### Claim 18 (depends on 4)

The pharmaceutical composition of claim 4, wherein the pharmaceutically acceptable salt is a hydrochloride salt.