# US 10,246,426 B2 · Triazole compounds as T-type calcium channel blockers

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- Number: US 10,246,426 B2
- Document ID: US10246426B2
- Status: Granted
- Kind: B2
- Application number: 15/510,980
- Filed: 2015-09-14
- Published: 2018-08-16
- Granted: 2019-04-02
- Earliest claimed: 2014-09-15
- Assignees: Idorsia Pharmaceuticals Ltd
- Applicants: Idorsia Pharmaceuticals Ltd
- Inventors: Olivier Bezencon; John Gatfield; Bibia Heidmann; Romain Siegrist; Simon Stamm
- Web page: https://patentgrep.com/patent/US10246426B2

## CPC

- C07D 249/04: 1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- A61P 3/10: for hyperglycaemia, e.g. antidiabetics
- A61P 9/00: Drugs for disorders of the cardiovascular system
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61P 15/08: for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 25/08: Antiepileptics; Anticonvulsants
- A61P 25/20: Hypnotics; Sedatives
- A61P 25/28: for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A61P 35/00: Antineoplastic agents
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 401/10: linked by a carbon chain containing aromatic rings
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 401/14: containing three or more hetero rings
- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 403/10: linked by a carbon chain containing aromatic rings
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 471/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to compounds of formula (I) wherein X, Y, R1, R2, (R4)n, and (R5)m are as defined in the description, and to pharmaceutically acceptable salts of such compounds. These compounds are useful as calcium T-channel blockers.

## Claims

### Claim 1

A compound of formula (I)
wherein
X represents a ring carbon or a ring nitrogen atom;
R1 represents
(C2-6)alkyl;
(C2-4)alkyl mono-substituted with cyano, or (C1-3)alkoxy;
(C1-4)fluoroalkyl;
(C1-3)fluoroalkoxy;
pentafluoro-sulfanyl;
(C3-6)cycloalkyl-L1- wherein
said (C3-6)cycloalkyl optionally contains one ring oxygen atom; wherein said (C3-6)cycloalkyl is unsubstituted; or mono-substituted with fluoro, (C1-3)alkyl, (C1-3)alkoxy, hydroxy, cyano, or (C1-3)fluoroalkyl; or di-substituted with fluoro, or tri-substituted with two fluoro substituents and a (C1-3)alkyl substituent; and
the linker L1 represents a direct bond, (C1-2)alkylene, oxygen, or (C1-2)alkylene-oxy;
5- or 6-membered heteroaryl, independently optionally mono-substituted with (C1-3)alkyl;
—NR11R12, wherein
R11 and R12 independently represent hydrogen, (C1-3)alkyl, (C2-3)fluoroalkyl, (C3-6)cycloalkyl, (C3-6)cycloalkyl mono- or di-substituted with fluoro, (C3-6)cycloalkyl-(C1-3)alkyl, (C1-3)alkoxy-(C2-3)alkyl;
or R11 and R12, together with the nitrogen atom to which they are attached to, form a 4- to -6 membered ring which is optionally mono- or di-substituted with fluoro; a 2-oxo-pyrrolidinyl group; or a morpholinyl group;
and (R4)n represents one or two optional substituents independently selected from (C1-4)alkyl, (C1-4)alkoxy, (C1-3)fluoroalkyl, (C1-3)fluoroalkoxy, halogen, and cyano;
or R1 together with (R4)n forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring; wherein said 5- or 6-membered ring optionally contains one or two heteroatoms independently selected from oxygen and nitrogen; wherein said fused 5- or 6-membered non-aromatic ring independently is optionally further mono-substituted with oxo; or di-, tri-, or tetra-substituted wherein one substituent is oxo and the remaining are (C1-3)alkyl;
or R1 together with (R4)n forms an aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring; wherein said 5- or 6-membered ring optionally contains one or two nitrogen atoms, wherein said fused 5- or 6-membered aromatic ring independently is optionally further mono- or di-substituted wherein the substituents are independently selected from (C1-4)alkyl, (C3-6)cycloalkyl, (C1)fluoroalkyl, or cyano;
Y represents a ring carbon or a ring nitrogen atom; and
R2 represents (C1-4)alkyl; (C3-6)cycloalkyl; (C1-4)alkoxy; (C3-6)cycloalkyl-oxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; (C1-3)alkoxy-(C2-3)alkoxy; halogen; cyano; or —NR21R22, wherein R21 and R22 independently represent hydrogen, or (C1-3)alkyl, or R21 and R22, together with the nitrogen atom to which they are attached to, form a 4- to -6 membered ring optionally mono- or di-substituted with fluoro, or a morpholinyl group;
and
(R5)m represents one or two optional substituents independently selected from (C1-4)alkyl; (C3-6)cycloalkyl; (C1-4)alkoxy; halogen; cyano; (C1-3)fluoroalkyl; and (C1-3)fluoroalkoxy;
or a salt of such a compound.

### Claim 2 (depends on 1)

A compound according to claim 1, wherein X represents a ring carbon atom; or a salt of such a compound.

### Claim 3 (depends on 1)

A compound according to claim 1, wherein
R1 represents
(C2-6)alkyl;
(C2-4)alkyl mono-substituted with cyano, or (C1-3)alkoxy;
(C1-4)fluoroalkyl;
(C1-3)fluoroalkoxy;
pentafluoro-sulfanyl;
(C3-6)cycloalkyl-L1- wherein
said (C3-6)cycloalkyl optionally contains one ring oxygen atom; wherein said (C3-6)cycloalkyl is unsubstituted, or mono-substituted with fluoro, (C1-3)alkyl, (C1-3)alkoxy, hydroxy, cyano, or (C1-3)fluoroalkyl, or di-substituted with fluoro, or tri-substituted with two fluoro substituents and a (C1-3)alkyl substituent; and
the linker L1 represents a direct bond, (C1-2)alkylene, oxygen, or (C1-2)alkylene-oxy;
—NR11R12, wherein
R11 and R12 independently represent hydrogen, (C1-3)alkyl, (C2-3)fluoroalkyl, (C3-6)cycloalkyl, (C3-6)cycloalkyl mono- or di-substituted with fluoro, (C3-6)cycloalkyl-(C1-3)alkyl;
or R11 and R12, together with the nitrogen atom to which they are attached to, form an azetidinyl or a pyrrolidinyl ring, both independently optionally mono- or di-substituted with fluoro;
and (R4)n represents one optional substituent selected from (C1-4)alkyl, (C1-4)alkoxy, (C1-3)fluoroalkyl, (C1-3)fluoroalkoxy, halogen, and cyano;
or R1 together with (R4)n forms a non-aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring to form a bicyclic ring system; wherein said bicyclic ring system is selected from 2,3-dihydro-benzooxazolyl, 3,4-dihydro-2H-benzo[1,4]oxazinyl, 2,3-dihydro-1H-indolyl, and 2,3-dihydro-benzofuranyl; wherein said non-aromatic 5- or 6-membered ring part of said bicyclic ring system independently is optionally further mono-substituted with oxo; or di-, tri-, or tetra-substituted wherein one substituent is oxo and the remaining are (C1-3)alkyl;
or R1 together with (R4)n forms an aromatic 5- or 6-membered ring which is fused to the phenyl/pyridine ring to form a bicyclic aromatic ring system selected from pyrazolo[3,4-b]pyridinyl, pyrrolo[2,3-b]pyridinyl, indolyl, indazolyl, quinoxalinyl, benzoimidazolyl, and quinolinyl; wherein said fused 5- or 6-membered aromatic ring part of said aromatic bicyclic ring system independently is optionally further mono- or di-substituted wherein the substituents are independently selected from (C1-3)alkyl, (C3-6)cycloalkyl, (C1)fluoroalkyl, or cyano;
or a salt of such a compound.

### Claim 4 (depends on 1)

A compound according to claim 1, wherein
R1 represents
(C2-6)alkyl;
(C1-4)fluoroalkyl;
(C1-3)fluoroalkoxy;
(C3-6)cycloalkyl wherein
said (C3-6)cycloalkyl optionally contains one ring oxygen atom; wherein said (C3-6)cycloalkyl is mono-substituted with fluoro or (C1-3)fluoroalkyl, or di-substituted with fluoro; or
(C3-6)cycloalkyl-oxy- wherein
said (C3-6)cycloalkyl optionally contains one ring oxygen atom; wherein said (C3-6)cycloalkyl is unsubstituted, or di-substituted with fluoro;
and (R4)n represents one optional substituent selected from (C1-4)alkyl, or halogen;
or a salt of such a compound.

### Claim 5 (depends on 1)

A compound according to claim 1, wherein the fragment
represents 4-isopropyl-phenyl, 4-dimethylamino-phenyl, 4-trifluoromethyl-phenyl, 4-tert.-butyl-phenyl, 4-(1-methoxy-ethyl)-phenyl, 4-(cyclopropyl-oxy)-phenyl, 4-(oxetan-3-yl)-phenyl, 4-(3-fluoro-oxetan-3-yl)-phenyl, 4-(cyclobutyl-oxy)-phenyl, 4-(3-methyl-oxetan-3-yl)-phenyl, 4-(1-cyano-cyclopropyl)-phenyl, 4-(1-cyano-1-methyl-ethyl)-phenyl, 4-(pentafluoro-sulfanyl)-phenyl, 3-methyl-4-(2,2,2-trifluoroethoxy)-phenyl, 4-(3-methoxy-oxetan-3-yl)-phenyl, 4-(oxetan-3-yl-methoxy)-phenyl, 4-(2-trifluoromethyl-cyclopropyl)-phenyl, 4-(1-trifluoromethyl-cyclopropyl)-phenyl, 4-((3-fluoro-oxetan-3-yl)-methoxy)-phenyl, 4-((3-methyl-oxetan-3-yl)-methoxy)-phenyl, 4-(3,3-difluoro-cyclobutyl-oxy)-phenyl, 4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl, 4-((3,3-difluoro-cyclobutyl)-methoxy)-phenyl, 4-((3,3-difluoro-1-methyl-cyclobutyl)-methoxy)-phenyl; 2-(pyrrolidin-1-yl)-pyridin-5-yl, 2-(cyclopropyl(methyl)amino)-pyridin-5-yl, 2-(diethylamino)-pyridin-5-yl, 3-fluoro-2-(pyrrolidin-1-yl)-pyridin-5-yl, 2-((cyclopropylmethyl)-methyl-amino)-pyridin-5-yl, 2-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-5-yl; 3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl, 1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl, 1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl, 1H-indol-5-yl, 1H-indol-6-yl, 1-methyl-1H-indazol-5-yl, 1-methyl-1H-indazol-6-yl, 1-ethyl-1H-indazol-5-yl, 1,3-dimethyl-1H-indazol-5-yl, 1-propyl-1H-indazol-5-yl, 1-isopropyl-1H-indazol-5-yl, 1-butyl-1H-indazol-5-yl, 3-butyl-1H-indazol-5-yl, 3-trifluoromethyl-1H-indazol-5-yl, 3-cyclopropyl-1H-indazol-5-yl, 3-cyclopropyl-1-methyl-1H-indazol-5-yl, 1-methyl-1H-indol-5-yl, 2-methyl-1H-indol-5-yl, 1,3-dimethyl-1H-indol-5-yl, or 1,3-dimethyl-1H-indol-6-yl;
or a salt of such a compound.

### Claim 6 (depends on 1)

A compound according to claim 1, wherein
Y represents a ring carbon or a nitrogen atom;
R2 represents (C1-4)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkyl; (C1-3)fluoroalkoxy; (C1-3)alkoxy-(C2-3)alkoxy; halogen; or cyano; and
(R5)m represents one or two optional substituents independently selected from (C1-4)alkyl; (C1-4)alkoxy; halogen; cyano; (C1-3)fluoroalkyl; and (C1-3)fluoroalkoxy;
or a salt of such a compound.

### Claim 7 (depends on 1)

A compound according to claim 1, wherein
Y represents a ring nitrogen atom; and
R2 represents cyano; and
(R5)m is absent; or
Y represents a ring carbon atom; and
R2 represents (C1-4)alkyl; (C1-4)alkoxy; (C1-3)fluoroalkoxy; (C1-3)alkoxy-(C2-3)alkoxy; halogen; or cyano; and
(R5)m represents one or two optional substituents independently selected from (C1-4)alkyl; (C1-4)alkoxy; halogen; and cyano;
or a salt of such a compound.

### Claim 8 (depends on 1)

A compound according to claim 1, wherein the fragment
represents 4-fluorophenyl, 4-methylphenyl, 4-fluoro-3-cyano-phenyl, 3,4-difluorophenyl, 3,5-difluoro-4-methoxy-phenyl, 3-fluoro-4-methoxy-phenyl, 4-cyano-3-fluoro-phenyl, 4-cyano-3-methyl-phenyl, 3-cyano-4-methyl-phenyl, 4-methoxyphenyl, 4-ethoxyphenyl, 3,4-dimethoxyphenyl, 4-fluoro-3-methoxy-phenyl; 3,4-difluoro-5-methoxy-phenyl, 3-cyano-4-methoxy-phenyl, 4-cyano-3-methoxy-phenyl, 4-cyano-3-fluoro-5-methoxy-phenyl, 4-cyanophenyl, 4-(2-methoxy-ethoxy)-phenyl, 4-difluoromethoxy-phenyl, 4-trifluoromethoxy-phenyl, 3-fluoro-4-difluoromethoxy-phenyl; 3-fluoro-4-trifluoromethoxy-phenyl; or 5-cyano-pyridin-2-yl;
or a salt of such a compound.

### Claim 9 (depends on 1)

A compound according to claim 1 selected from the group consisting of N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
2-(4-Dimethylamino-phenyl)-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1H-indol-6-yl)-acetamide;
2-(4-Cyclobutoxy-phenyl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-Cyclopropoxy-phenyl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(Cyclopropyl(methyl)amino)-pyridin-3-yl]-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(Cyclopropylmethyl-methyl-amino)-pyridin-3-yl]-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-methoxy-ethyl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1H-indol-5-yl)-acetamide;
2-(6-Diethylamino-pyridin-3-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3,3-trimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-oxetan-3-yl-phenyl)-acetamide; 2-(4-Isopropyl-phenyl)-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-Isopropyl-phenyl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;
2-(3-Cyclopropyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(1-Butyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(2-methyl-1H-indol-5-yl)-acetamide;
2-(3-Butyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-isopropyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-propyl-1H-indazol-5-yl)-acetamide;
2-(3-Cyclopropyl-1-methyl-1H-indazol-5-yl)-N-[2-(3,4-difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-acetamide;
N-[2-(3,4-Difluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(3-trifluoromethyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Ethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
2-(6-Diethylamino-pyridin-3-yl)-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3,4-dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(3,4-Dimethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
2-(6-Diethylamino-pyridin-3-yl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyri din-3-yl)-acetamide;
N-[2-(4-Methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3,5-difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-{2-[4-(2-methoxy-ethoxy)-benzyl]-2H-[1,2,3]triazol-4-yl}-acetamide;
N-{2-[4-(2-Methoxy-ethoxy)-benzyl]-2H-[1,2,3]triazol-4-yl}-2-(1-methyl-1H-indol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-difluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Difluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 2-(1-Methyl-1H-indol-5-yl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(1-Methyl-1H-indazol-5-yl)-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[4-(3-Methyl-oxetan-3-yl)-phenyl]-N-[2-(4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(6-Diethylamino-pyridin-3-yl)-N-[2-(4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; 2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-propyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-6-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-6-yl)-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
2-[4-(3,3-Difluoro-cyclobutylmethoxy)-phenyl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
2-(1-Ethyl-1H-indazol-5-yl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(1,3-Dimethyl-1H-indol-5-yl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
2-(1-Ethyl-H-indazol-5-yl)-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(1,3-Dimethyl-1H-indol-5-yl)-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3-fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3,5-difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,5-Difluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(4-Fluoro-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(3-Fluoro-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
2-[4-(Cyano-dimethyl-methyl)-phenyl]-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-fluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-trifluoromethyl-phenyl)-acetamide; N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(5-fluoro-6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3-Cyano-4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Cyano-4-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-1-methyl-cyclobutylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(4-Difluoromethoxy-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
2-[6-(3,3-Difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(1-Ethyl-1H-indazol-5-yl)-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(1,3-Dimethyl-1H-indazol-5-yl)-N-[2-(3-fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3-Fluoro-4-trifluoromethoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methyl-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-1-methyl-cyclobutylmethoxy)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide; 2-(4-tert-Butyl-phenyl)-N-[2-(3-cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(3,4-difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[6-(3,3-difluoro-pyrrolidin-1-yl)-pyridin-3-yl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-ethyl-1H-indazol-5-yl)-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(4-isopropyl-phenyl)-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-6-yl)-acetamide;
N-[2-(3-Cyano-4-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-ylmethoxy)-phenyl]-acetamide;
2-[4-(3,3-Difluoro-cyclobutoxy)-phenyl]-N-[2-(3,4-difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
2-[4-(1-Cyano-cyclopropyl)-phenyl]-N-[2-(4-cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-(2-(4-cyano-3-fluorobenzyl)-2H-1,2,3-triazol-4-yl)-2-(4-(pentafluorosulfanyl)phenyl)acetamide;
N-[2-(4-Cyano-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1-methyl-1H-indazol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-fluoro-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(3-Cyano-4-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3-methoxy-oxetan-3-yl)-phenyl]-acetamide;
N-[2-(4-Cyano-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutylmethoxy)-phenyl]-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(4-cyano-3-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-acetamide;
N-[2-(3,4-Difluoro-5-methoxy-benzyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;
N-[2-(4-Cyano-3-methyl-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-[3-methyl-4-(2,2,2-trifluoro-ethoxy)-phenyl]-acetamide;
N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-(1,3-dimethyl-1H-indol-5-yl)-acetamide;
2-(4-tert-Butyl-phenyl)-N-[2-(5-cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-acetamide; N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(1-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(3,3-difluoro-cyclobutoxy)-phenyl]-acetamide;
N-[2-(5-Cyano-pyridin-2-ylmethyl)-2H-[1,2,3]triazol-4-yl]-2-(5-fluoro-6-pyrrolidin-1-yl-pyridin-3-yl)-acetamide;
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-phenyl]-acetamide; and
N-[2-(4-Cyano-3-fluoro-benzyl)-2H-[1,2,3]triazol-4-yl]-2-[4-((1S*,2S*)-2-trifluoromethyl-cyclopropyl)-phenyl]-acetamide;
or a salt of such a compound.

### Claim 10 (depends on 1)

A pharmaceutical composition containing, as active principle, a compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

### Claim 11 (depends on 1)

A compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, for use as a medicament.

### Claim 12 (depends on 1)

A compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, for use in the treatment of epilepsy; sleep disorders; sleep disturbances; pain; neurological disorders; cardiovascular disorders; cancer; diabetes; diabetic neuropathy; infertility; and sexual dysfunction.

### Claim 13 (depends on 1)

A method of treating a disease comprising administering a pharmaceutically active amount of the compound of formula (I) according to claim 1, or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the disease is selected from epilepsy; sleep disorders; sleep disturbances; pain; neurological disorders; cardiovascular disorders; cancer; diabetes; diabetic neuropathy; infertility; and sexual dysfunction.