# US 10,246,421 B2 · Indazolyl- and indolyl-benzamide derivatives

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- Number: US 10,246,421 B2
- Document ID: US10246421B2
- Status: Granted
- Kind: B2
- Application number: 14/851,542
- Filed: 2015-09-11
- Published: 2016-03-17
- Granted: 2019-04-02
- Earliest claimed: 2014-09-11
- Assignees: Esanex, Inc.
- Applicants: Esanex, Inc.
- Inventors: Philip F. Hughes
- Web page: https://patentgrep.com/patent/US10246421B2

## CPC

- C07D 231/54: condensed with carbocyclic rings or ring systems
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 31/00: Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P 31/14: for RNA viruses
- A61P 31/18: for HIV
- A61P 31/20: for DNA viruses
- A61P 35/00: Antineoplastic agents
- C07D 401/12: linked by a chain containing hetero atoms as chain links
- C07D 403/12: linked by a chain containing hetero atoms as chain links
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 409/12: linked by a chain containing hetero atoms as chain links
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to indazolylbenzamide, indolylbenzamide, benzo[d]imidazolyl-benzamide, and benzo[d]triazolylbenzamide derivatives of formula useful in the treatment and/or prevention of diseases and/or conditions related to cell proliferation, such as cancer, infection, inflammation and inflammation-associated disorders, and conditions associated with angiogenesis.

## Claims

### Claim 1

A compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein
bond “” is a single or a double bond;
R3 is hydrogen, halogen, cyano, —C(O)OH, —C(O)—O(C1-C6 alkyl), —N(RN)2, C1-C6 alkyl,
C1-C6 alkoxy, C1-C6 haloalkyl, C3-C7 cycloalkyl, aryl, or heteroaryl, wherein;
each alkyl, cycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide; and each RN is independently hydrogen or —C1-C6 alkyl-;
R4 and R5 are independently hydrogen or halogen;
R6 is halogen or —Z1RZ1, and wherein
Z1 is —O—, —NH—, —S(O)p—, or —S(O)2NH—, wherein p is 0, 1 or 2; and
RZ1 is a C1-C14 alkyl group where up to five of the carbon atoms in the alkyl group are optionally replaced independently by R22, carbonyl, ethenyl, ethynyl or a moiety selected from N, O, S, SO2, and SO, with the proviso that two O atoms, two S atoms, or an O and S atom are not immediately adjacent to each other, and
R22 is heteroaryl, aryl, saturated or unsaturated C3-C10 cycloalkyl, or saturated or unsaturated C2-C10 heterocycloalkyl, wherein each aryl, heteroaryl, saturated or unsaturated cycloalkyl, or saturated or unsaturated heterocycloalkyl, independently, is optionally substituted with at least one group, which independently is hydroxy, halo, amino, cyano, carboxy, carboxamido, nitro, oxo, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, (C1-C6)alkoxy, or mono- or di-(C1-C10)alkylamino; and wherein each is optionally fused to a C6-C10 aryl group, C5-C8 saturated cyclic group, or a C5-C10 heterocycloalkyl group;
and wherein RZ1 optionally substituted at any available position independently with C1-C10 alkyl, C1-C10 haloalkyl, C2-C10 alkenyl, C2-C10 alkynyl, hydroxy, carboxy, carboxamido, oxo, halo, amino, cyano, nitro, —SH, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, C1-C6 alkoxy, C2-C10 alkenyloxy, C2-C10 alkynyloxy, mono- or di-(C1-C10)alkylamino, —OC1-C10 alkyl-Z, or R23, wherein
Z is OR31 or —N(R30)2, wherein
each R30 is independently hydrogen or C1-C6 alkyl, or N(R30)2 represents pyrrolidinyl, piperidinyl, piperazinyl, azepanyl, 1,3- or 1,4-diazepanyl, or morpholinyl, each of which is optionally substituted with hydroxy, amino, aminoalkyl, C1-C6 alkyl, mono- or di(C1-C6)alkylamino, C1-C6 alkoxy, or halogen;
R31 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, aryl, heteroaryl, or C1-C6 acyl;
R23 is heteroaryl, aryl, saturated or unsaturated C5-C10 cycloalkyl, or saturated or unsaturated C5-C10 heterocycloalkyl, and each is optionally substituted with at least one group which is independently hydroxy, oxo, halo, amino, cyano, nitro, —SH, —S—(C1-C6)alkyl, —SO2-(C1-C6)alkyl, —SO2-aryl, —SO—(C1-C6)alkyl, —SO-aryl, —SO2NH2, —SO2NH—(C1-C6)alkyl, —SO2NH-aryl, C1-C6 alkoxy, or mono- or di-(C1-C10)alkylamino;
R9 and R10 are independently hydrogen or C1-C8 alkyl; or R9 and R10 taken together with the carbon atom to which they are attached form C3-C8 cycloalkyl;
R1 is hydrogen, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C1-C10 alkoxy, mono- or di-(C1-C10)alkylamino, C1-C10 alkoxy(C1-C10)alkyl, hydroxy(C1-C10) alkoxy, or amino(C1-C10)alkoxy-;
R41 is a group of the formula
wherein
R1 and R2 are independently H, hydroxy, C2-C6 alkenyl, C2-C6 alkynyl, heteroaryl, aryl, C3-C8 cycloalkyl, heterocycloalkyl, wherein
each cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide;
X4 is oxygen;
X is N or CRC; and
Y is N or CRC;
each RC is independently is hydrogen, halogen, cyano, nitro, —C(O)RC1, C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl(C1-C10)alkyl, heterocycloalkyl, aryl, or heteroaryl, wherein
each alkyl, aryl, cycloalkyl, heterocycloalkyl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, cyano, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, carboxamide, heterocycloalkyl, aryl, or heteroaryl, wherein the aryl and heteroaryl groups are optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, halo(C1-C6)alkyl, or carboxamide;
RC1 is —C1-C6 alkyl, —ORC2, or —N(RCN)2, wherein
RC2 is —H, C1-C10 alkyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
each RCN is independently —H, C1-C10 alkyl, C1-C10 haloalkyl, C3-C7 cycloalkyl, heterocycloalkyl, C1-C6 acyl, aryl, or heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl group is optionally substituted with from 1-4 groups that are independently C1-C6 alkyl, C1-C6 alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6) alkylamino, nitro, halo(C1-C6)alkyl, halo(C1-C6)alkoxy, or carboxamide.

### Claim 2 (depends on 1)

A compound of claim 1, wherein Z1 is —O— or —NH—.

### Claim 3 (depends on 1)

A compound according to claim 1, wherein Re is —Z1RZ1, wherein
Z, is —NH— and
RZ1 is (C1-C14)alkyl, (C2-C14)alkenyl, (C2-C14)alkynyl, aryl, aryl(C1-C8)alkyl, (C3-C8)cycloalkenyl, (C3-C8)cycloalkenyl(C1-C8)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C8)alkyl, heteroaryl, heteroaryl(C1-C8)alkyl, heteroaryl(C1-C8)alkylthio(C1-C8)alkyl, heteroarylthio(C1-C8)alkyl, heterocyclyl, heterocycle(C1-C8)alkyl, or hydroxy(C1-C8)alkyl,
wherein each is optionally substituted with 1, 2, 3, 4, or 5 groups which are independently (C2-C8)alkenyl, (C1-C8)alkoxy, (C1-C8)alkoxy(C1-C8)alkyl, (C1-C8)alkoxycarbonyl, (C1-C8)alkyl, (C1-C8)alkylcarbonyl, (C1-C8)alkylcarbonyloxy, (C1-C8)alkylsulfinyl, (C1-C8)alkylsulfonyl, (C1-C8)alkylthio, (C2-C8)alkynyl, carboxy, carboxy(C1-C8)alkyl, cyano, cyano(C1-C8)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C8)alkyl, formyl, halo(C1-C8)alkoxy, halo(C1-C8)alkyl, halogen, hydroxy, hydroxy(C1-C8)alkoxy, hydroxy(C1-C8)alkoxy(C1-C8)alkoxy, hydroxy(C1-C8)alkyl, mercapto, nitro, —NR12R13, (NR12R13)(C1-C8)alkyl, (NR12R13)carbonyl, oxo, HOCH2CH(NH2)C(O)O—, NH2(CH2)mC(O)O—, CH3NH(CH2)mC(O)O—, (CH3)2N(CH2)mC(O)O—, NH2(CH2)tC(O)NH(CH2)mC(O)O—, R13CH(NH2)C(O)O—, NH2(CH2)mC(R13)2(CH2)mC(O)O—, NH2CH2CH2C(O)O—, R12ON═CH(CH2)nO—, HONHC(O)(CH2)nO—, —OP(O)(ORP)2, —OS(O)2ORS, or R20;
where each m is independently 1, 2, 3, or 4;
where each n is 1, 2, 3, 4, 5, or 6;
where t is 1, 2, 3, or 4;
where R12 and R13 are independently —H, (C2-C8)alkenyl, (C1-C8)alkyl, (C1-C8)alkylcarbonyl, (C2-C8)alkynyl, aryl, aryl(C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C8)alkyl, formyl, heteroaryl, heteroaryl(C1-C8)alkyl, heterocyclyl, or heterocycle(C1-C8)alkyl; or two R12 groups together with the carbon to which they are attached form a (C3-C8)cycloalkyl group;
where each RP and RS is independently hydrogen, (C1-C6)alkyl, (C1-C6)haloalkyl, or aryl, wherein the alkyl or aryl is optionally substituted with one or more groups independently selected from (C1-C6)alkyl, (C1-C6)alkoxy, halogen, hydroxy, amino, mono- or di-(C1-C6)alkylamino, nitro, halo(C1-C6)alkyl, carboxy, or carboxamide; and
where R20 is:
wherein
d and k are integers independently selected from 1 and 2;
R201 is (C1-C6)alkyl where the alkyl is optionally substituted with (C3-C7)cycloalkyl, (C2-C6) alkenyl, (C2-C6)alkynyl, hydroxy, halogen, nitro, or cyano; and
T is O or NR202 where R202 is hydrogen or (C1-C6)alkyl; and
R301 and R302 are independently hydrogen or (C1-C6)alkyl, and
R303 is absent, hydrogen, or (C1-C6)alkyl.

### Claim 4 (depends on 3)

A compound according to claim 3, wherein R1 and R2 are hydrogen.

### Claim 5 (depends on 1)

A compound according to claim 1, where X is N.

### Claim 6 (depends on 1)

A compound according to claim 1, of formula:

### Claim 7 (depends on 6)

A compound according to claim 6, wherein RC is hydrogen, C1-C10 alkyl, or C1-C10 haloalkyl.

### Claim 8 (depends on 1)

A compound according to claim 1, wherein bond “” is a single bond.

### Claim 9 (depends on 1)

A compound according to claim 1, wherein R11 is hydrogen, C1-C10 alkyl, C1-C10 haloalkyl, C1-C10 alkoxy, mono- or di-(C1-C10)alkylamino, C1-C10 alkoxy(C1-C10)alkyl, hydroxy(C1-C10) alkoxy, or amino(C1-C10)alkoxy-.

### Claim 10 (depends on 9)

A compound according to claim 9, wherein R11 is hydrogen or C1-C10 alkyl.

### Claim 11 (depends on 10)

A compound according to claim 10, wherein R11 is hydrogen.

### Claim 12 (depends on 1)

A compound according to claim 1, wherein R3 is hydrogen, halogen, C1-C6 alkoxy, or C1-C6 haloalkyl; R4 is hydrogen, and R5 is hydrogen.

### Claim 13 (depends on 12)

A compound according to claim 12, wherein R3 is halogen.

### Claim 14 (depends on 3)

A compound according to claim 3, where RZ1 is aryl, aryl(C1-C8)alkyl, C3-C8 cycloalkyl, (C3-C8)cycloalkyl(C1-C8)alkyl, heteroaryl, heteroaryl(C1-C8)alkyl, heterocyclyl, or heterocycle(C1-C8)alkyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups which are independently (C2-C8)alkenyl, (C1-C8)alkoxy, (C1-C8)alkoxy(C1-C8)alkyl, (C1-C8)alkoxycarbonyl, (C1-C8)alkyl, (C1-C8)alkylcarbonyl, (C1-C8)alkylcarbonyloxy, (C1-C8)alkylsulfinyl, (C1-C8)alkylsulfonyl, (C1-C8)alkylthio, (C2-C8)alkynyl, carboxy, carboxy(C1-C8)alkyl, cyano, cyano(C1-C8)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C8)alkyl, formyl, halo(C1-C8)alkoxy, halo(C1-C8)alkyl, halogen, hydroxy, hydroxy(C1-C8)alkoxy, hydroxy(C1-C8)alkoxy(C1-C8)alkoxy, hydroxy(C1-C8)alkyl, mercapto, nitro, —NR12R13, (NR12R13)(C1-C8)alkyl, (NR12R13)carbonyl, oxo, HOCH2CH(NH2)C(O)O—, NH2(CH2)mC(O)O—, CH3NH(CH2)mC(O)O—, (CH3)2N(CH2)mC(O)O—, NH2(CH2)tC(O)NH(CH2)mC(O)O—, R13CH(NH2)C(O)O—, NH2(CH2)mC(R13)2(CH2)mC(O)O—, NH2CH2CH2C(O)O—, R12ON═CH(CH2)nO—, HONHC(O)(CH2)nO—, —OP(O)(ORP)2, —OS(O)2ORS, or R20.

### Claim 15 (depends on 3)

A compound according to claim 3, where RZ1 is C3-C8 cycloalkyl or heterocyclyl, each of which is optionally substituted with 1, 2, 3, 4, or 5 groups which are independently (C1-C8)alkoxy, carboxy, cyano, formyl, halo(C1-C8)alkoxy, halo(C1-C8)alkyl, halogen, hydroxy, hydroxy(C1-C8)alkoxy, hydroxy(C1-C8)alkoxy(C1-C8)alkoxy, —NR12R13, —OP(O)(ORP)2, —OS(O)2ORS, or R20.

### Claim 16 (depends on 3)

A compound according to claim 3, where RZ1 is cyclopentyl or cyclohexyl, each of which is substituted with 1, or 2, or 3 groups independently selected from hydroxy, C1-C8 alkoxy, and (C1-C8)alkylcarbonyloxy.

### Claim 17 (depends on 1)

A compound according to claim 1, which is:
2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(4-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide;
2-(cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-6,7-dihydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1r,4r)-4-hydroxycyclohexylamino)-4-(3,4,6,6-tetramethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1r,4r)-4-hydroxycyclohexylamino)-4-(3,4,6,6-tetramethyl-6,7-dihydro-1H-indazol-1-yl)benzamide; or
a pharmaceutically acceptable salt thereof.

### Claim 18 (depends on 1)

A compound according to claim 1 which is
2-(trans-4-(cyclopropylmethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(trans-4-methoxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(trans-4-hydroxycyclohexylamino)-4-(3-(hydroxymethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2,3,5-trifluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
2-fluoro-6-(2-oxoazepan-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(2-hydroxyethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(2-(isobutylamino)ethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1,3-dihydroxypropan-2-ylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
(S)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(piperidin-3-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-neopentylpiperidin-3-ylamino)benzamide;
2-((1S,2S)-2-aminocyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1S,2S)-2-(neopentylamino)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(2-((1H-imidazol-2-yl)methylthio)ethylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
2-(cyclopent-3-enylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)pyrrolidin-3-ylamino)benzamide;
2-(cyclobutylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxypropylamino)benzamide;
2-(trans-4-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(((S)tetrahydrofuran-3-yl)amino)-4-(4,6,6-trimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((tetrahydrofuran-3-yl)amino)benzamide;
2-fluoro-6-(((1S,2S)-2-hydroxycyclopentyl)amino)-4-(3,4,6,6-tetramethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(((1r,4r)-4-hydroxycylohexyl)amino)benzamide;
2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(4,6,6-trimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)-2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)benzamide;
2-fluoro-6-(((1r,4r)-4-hydroxycyclohexyl)amino)-4-(4,6,6-trimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(S)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopentylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate hydrochloride;
(1S,2S)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate maleate;
(trans)-4-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate hydrochloride;
trans-4-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate methanesulfonate;
2-(cyclopentylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate methanesulfonate;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate methanesulfonate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate methanesulfonate;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)-6-methoxybenzamide;
5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-((trans)-4-hydroxycyclohexylamino)picolinamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
2-(4,4-Difluoro-cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-indazol-1-yl)-benzamide;
2-(cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
trans-4-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-(tert-butoxycarbonylamino)acetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-(tert-butoxycarbonylamino)acetate;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
(S)-2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-2-fluoro-6-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-aminocyclohexylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopropylmethylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(((1S,2S)-2-hydroxycyclohexyl)amino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-6,7-dihydro-1H-indazol-1-yl)-2-fluoro-6-(((1S,2S)-2-hydroxycyclohexyl)amino)benzamide;
(S)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(R)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
(S)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
(R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(2-hydroxyethylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluoro-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
(R)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-5-fluoro-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-((R)-tetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-((R)-tetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-(neopentylamino)cyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-(neopentylamino)cyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(2-oxotetrahydrofuran-3-ylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3,5-difluoro-2-(trans-4-hydroxycyclohexylamino)benzamide;
methyl 2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)-4-hydroxybutanoate;
2-(cyclopent-3-enylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
2-(1-acetylpiperidin-4-ylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(2-oxotetrahydrofuran-3-ylamino)benzamide;
2-fluoro-6-(4-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(2-oxotetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(2-oxoazepan-3-ylamino)benzamide;
2-(2,2-dimethoxyethylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(trans-4-methoxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2R)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2R)-2-hydroxycyclopentylamino)benzamide;
2-(cyclopentylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(trans)-4-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
(trans)-4-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(S)-2-fluoro-6-(6-oxotetrahydro-2H-pyran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-2-fluoro-6-(6-oxotetrahydro-2H-pyran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((cis)-4-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-(oxetan-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopentylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cycloheptylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(trans)-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclopentyl 2-aminoacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-3-fluorophenylamino)cyclohexyl 2-aminoacetate;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-fluoro-6-(tetrahydrofuran-3-ylamino)benzamide;
2-fluoro-6-((1S,2R)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(4,4-difluorocyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclopentylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-6-fluorobenzamide;
2-(cyclohexylamino)-6-fluoro-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-fluoro-6-((1R,2R)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(1R,2R)-2-(2-carbamoyl-3-fluoro-5-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate;
(S)-(trans-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl) 2-amino-3-hydroxypropanoate;
trans-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-(dimethylamino)acetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyrimidin-2-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyrimidin-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyrimidin-5-ylamino)benzamide;
4-(3-(difluoromethyl)-6,6-dimethyl-4, 5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-4-ylamino)benzamide;
2-(1-cyclopropylpiperidin-4-ylamino)-4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(2-methoxyethyl)piperidin-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(2-hydroxyethoxy)pyridin-4-ylamino)benzamide;
2-(1-(2-(methylamino)ethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-(prop-2-ynylamino)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-4-ylamino)benzamide;
2-(azetidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(diprop-2-ynylamino)ethylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(prop-2-ynylamino)ethylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-(prop-2-ynylamino)cyclohexylamino)benzamide;
2-(1-allylpiperidin-4-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1R,2R)-2-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1R,2S)-2-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-3-ylamino)benzamide;
(S)-2-(1-allylpiperidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(piperidin-3-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-(pyrimidin-2-ylthio)ethylamino)benzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-(prop-2-ynyl)piperidin-3-ylamino)benzamide;
(S)-2-(1-(cyclopropylmethyl)piperidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(cyclopropylmethyl)piperidin-4-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(3-aminocyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(1-(2-(tert-butylamino)ethyl)-1H-pyrazol-4-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(pyridazin-4-ylamino)benzamide;
(R)-2-(1-(cyclopropylmethyl)piperidin-3-ylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-(cyclopropylmethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(2-(1H-imidazol-2-ylthio)ethylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-(prop-2-ynylamino)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-(diprop-2-ynylamino)cyclohexylamino)benzamide;
2-((1R,2R)-2-(cyclopropylmethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1R,2R)-2-(bis(cyclopropylmethyl)amino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-(diethylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-(cyclopropylamino)cyclohexylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-(neopentylamino)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-(neopentylamino)cyclohexylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
4-(3-(difluoromethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2,2,6,6-tetramethylpiperidin-4-ylamino)benzamide;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-aminoacetate;
(1S,2S)-2-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclopentyl 1-aminocyclopropanecarboxylate methanesulfonate;
trans-4-(2-carbamoyl-5-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)phenylamino)cyclohexyl 2-(2-aminoacetamido)acetate 2,2,2-trifluoroacetate;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(4-(2-(methoxyimino)ethoxy)cyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(4-(2-(phenoxyimino)ethoxy)cyclohexylamino)benzamide;
2-(trans-4-(2-hydroxyethoxy)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(R)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(4-(2-(hydroxyamino)-2-oxoethoxy)cyclohexylamino)benzamide;
2-(trans-4-(2-(2-hydroxyethoxy)ethoxy)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclobutylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(4-(2-hydroxyethoxy)cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
2-(cyclobutylamino)-4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(trans-4-hydroxycyclohexylamino)-4-(3-(3-methoxyphenyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-benzyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(1H-pyrazol-4-yl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-2-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(3-benzyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(3-benzyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
(R)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-hydroxypropan-2-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(1-hydroxypropan-2-ylamino)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxypropylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(6,6-dimethyl-3-(thiophen-3-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(2-hydroxyethylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(pyridin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
(R)-4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1R,2R)-2-hydroxycyclopentylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
4-(3-(cyclopropylmethyl)-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclohexylamino)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2S)-2-hydroxycyclopentylamino)benzamide;
(S)-2-(tetrahydrofuran-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-((1S,2S)-2-hydroxycyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(oxetan-3-ylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
(S)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(tetrahydrofuran-3-ylamino)benzamide;
4-(6-ethyl-3,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((trans)-4-hydroxycyclohexylamino)benzamide;
2-(cyclopentylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cycloheptylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
4-(3-ethyl-6,6-dimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-methoxy-6-(tetrahydro-2H-pyran-4-ylamino)benzamide;
4-(6,6-dimethyl-3-(2,2,2-trifluoroethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-(trans-4-hydroxycyclohexylamino)benzamide;
4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)-2-((1S,2R)-2-hydroxycyclopentylamino)benzamide;
2-(cyclopentylamino)-4-(6,6-dimethyl-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide;
2-(cyclohexylamino)-4-(3,6,6-trimethyl-4,5,6,7-tetrahydro-1H-indazol-1-yl)benzamide; or
a pharmaceutically acceptable salt thereof.

### Claim 19 (depends on 1)

A pharmaceutical composition comprising at least one compound or salt according to claim 1 and a pharmaceutically acceptable solvent, carrier, excipient, adjuvant or a combination thereof.

### Claim 20 (depends on 1)

A method of treating an HSP-90-mediated disease which is cancer, inflammation, infection, or arthritis comprising administering to a patient in need of such treatment a therapeutically effective amount of an HSP-90 inhibiting compound or salt according to claim 1.

### Claim 21 (depends on 1)

A method for treating a subject suffering from a disease or disorder of proteins that are either client proteins for HSP-90 or indirectly affect its client proteins, comprising administering to a subject in need of such treatment a therapeutically effective amount of an HSP-90 inhibiting compound or salt according to claim 1.