# US 10,246,396 B1 · Vanillin having tetramer structure

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 10,246,396 B1
- Document ID: US10246396B1
- Status: Granted
- Kind: B1
- Application number: 15/943,977
- Filed: 2018-04-03
- Granted: 2019-04-02
- Earliest claimed: 2018-04-03
- Applicants: Tian-Jye Hsieh
- Inventors: Tian-Jye Hsieh
- Web page: https://patentgrep.com/patent/US10246396B1

## CPC

- C07C 47/58: Vanillin
- C07B 2200/13: Crystalline forms, e.g. polymorphs
- G01N 23/20075: {by measuring interferences of X-rays, e.g. Borrmann effect}
- G01N 24/087: {Structure determination of a chemical compound, e.g. of a biomolecule such as a protein}
- G16C 10/00: Computational theoretical chemistry, i.e. ICT specially adapted for theoretical aspects of quantum chemistry, molecular mechanics, molecular dynamics or the like
- G16C 20/30: Prediction of properties of chemical compounds, compositions or mixtures
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- G16C: COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE

## Abstract

A vanillin having a tetramer structure is revealed, comprising a first monomer, a second monomer, a third monomer, and a fourth monomer. Each of the monomers is constituted by C8H8O3. The vanillin includes a first intermolecular hydrogen bond between the first monomer and the fourth monomer, and a second intermolecular hydrogen bond between the second monomer and the third monomer to stabilize the tetramer structure.

## Claims

### Claim 1

A vanillin having a tetramer structure, comprising a first monomer, a second monomer, a third monomer, a fourth monomer, a first intermolecular hydrogen bond between the first monomer and the fourth monomer, and a second intermolecular hydrogen bond between the second monomer and the third monomer; wherein each of the monomers is constituted by C8H8O3.

### Claim 2 (depends on 1)

The vanillin having a tetramer structure as claimed in claim 1, wherein the first intermolecular hydrogen bond is formed between an oxygen atom of a methoxy group of the first monomer and a hydrogen atom of a hydroxyl group of the fourth monomer, and the second intermolecular hydrogen bond is formed between an oxygen atom of a methoxy group of the third monomer and a hydrogen atom of a hydroxyl group of the second monomer.

### Claim 3 (depends on 1)

The vanillin having a tetramer structure as claimed in claim 1, wherein the first intermolecular hydrogen bond has a bonding length of 1.875 Å, and the second intermolecular hydrogen bond has a bonding length of 1.818 Å.

### Claim 4 (depends on 1)

The vanillin having a tetramer structure as claimed in claim 1, wherein the vanillin has characteristics of 1H NMR (CDCl3) δ: 3.95 (3H, s, C3—OCH3), 6.20 (1H, br s, OH), 7.09 (1H, d, J=8.0 Hz, H-5), 7.30 (1H, d, J=2.0 Hz, H-2), 7.42 (1H, dd, J=8.0, 2.0 Hz, H-6), 9.76 (1H, s, CHO), and at 295 K, unit cell dimensions: a=14.0368(9) Å, b=7.8583(5) Å, c=14.9937(9) Å, α=90°, β=115.446(1)°, γ=90°, space group=P2(1), volume=1493.19(16) Å3, Z=8, and Dcalc=1.354 Mg/m3.